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    Mmgt2 membrane magnesium transporter 2 [ Mus musculus (house mouse) ]

    Gene ID: 216829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mmgt2provided by MGI
    Official Full Name
    membrane magnesium transporter 2provided by MGI
    Primary source
    MGI:MGI:2448491
    See related
    Ensembl:ENSMUSG00000048497 AllianceGenome:MGI:2448491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables magnesium ion transmembrane transporter activity and transition metal ion transmembrane transporter activity. Involved in magnesium ion transport. Acts upstream of or within transition metal ion transport. Located in Golgi apparatus; early endosome; and plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.2), limb E14.5 (RPKM 7.6) and 27 other tissues See more
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    Genomic context

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    See Mmgt2 in Genome Data Viewer
    Location:
    11 B2; 11 38.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62538999..62557185)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62648180..62666359)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene leucine rich repeat containing 75A, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62462281-62462390 Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. Goytain A, et al. Am J Physiol Cell Physiol, 2008 Feb. PMID 18057121
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36859

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cobalt ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inorganic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cobalt ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within copper ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within manganese ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nickel cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nickel cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane magnesium transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175002.2 → NP_778167.1  membrane magnesium transporter 2

      See identical proteins and their annotated locations for NP_778167.1

      Status: VALIDATED

      Source sequence(s)
      AK131977, AL596181, BB871237
      Consensus CDS
      CCDS36179.1
      UniProtKB/Swiss-Prot
      Q8R3L0
      Related
      ENSMUSP00000128697.2, ENSMUST00000155759.3
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62538999..62557185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248909.3 → XP_011247211.2  membrane magnesium transporter 2 isoform X1

    2. XM_036156560.1 → XP_036012453.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    3. XM_036156556.1 → XP_036012449.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    4. XM_036156558.1 → XP_036012451.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Related
      ENSMUSP00000128669.2, ENSMUST00000129162.3
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    5. XM_036156557.1 → XP_036012450.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    6. XM_006532870.2 → XP_006532933.1  membrane magnesium transporter 2 isoform X2

      See identical proteins and their annotated locations for XP_006532933.1

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    7. XM_036156559.1 → XP_036012452.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter

    8. XM_036156555.1 → XP_036012448.1  membrane magnesium transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L0
      Conserved Domains (1) summary
      pfam10270
      Location:12 → 90
      MMgT; Membrane magnesium transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3L0.1 GenPept UniProtKB/Swiss-Prot:Q8R3L0

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