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    Sarm1 sterile alpha and HEAT/Armadillo motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 237868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sarm1provided by MGI
    Official Full Name
    sterile alpha and HEAT/Armadillo motif containing 1provided by MGI
    Primary source
    MGI:MGI:2136419
    See related
    Ensembl:ENSMUSG00000050132 AllianceGenome:MGI:2136419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sarm; MyD885; A830091I15Rik
    Summary
    Enables NAD+ nucleosidase activity. Involved in several processes, including NAD catabolic process; regulation of dendrite morphogenesis; and regulation of synapse pruning. Acts upstream of or within regulation of neuron apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrial outer membrane. Part of protein-containing complex. Is active in cell surface and neuromuscular junction. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 11.0), CNS E18 (RPKM 9.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sarm1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78361099..78388642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78470273..78497816, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30367 Neighboring gene forkhead box N1 Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Neighboring gene solute carrier family 46, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene SEBOX homeobox Neighboring gene vitronectin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1. Bratkowski M, et al. Cell Rep, 2020 Aug 4. PMID 32755591
    2. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Shi Y, et al. Mol Cell, 2022 May 5. PMID 35334231, Free PMC Article
    3. A new form of axonal pathology in a spinal model of neuromyelitis optica. Herwerth M, et al. Brain, 2022 Jun 3. PMID 35202467, Free PMC Article
    4. SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration. Finnegan LK, et al. Int J Mol Sci, 2022 Jan 30. PMID 35163535, Free PMC Article
    5. SARM1 knockout does not rescue neuromuscular phenotypes in a Charcot-Marie-Tooth disease Type 1A mouse model. Moss KR, et al. J Peripher Nerv Syst, 2022 Mar. PMID 35137510, Free PMC Article

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment.
      Title: Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment.
    2. Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
      Title: Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
    3. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
      Title: SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
    4. SARM1 regulates NAD[+]-linked metabolism and select immune genes in macrophages.
      Title: SARM1 regulates NAD(+)-linked metabolism and select immune genes in macrophages.
    5. Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy.
      Title: Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy.
    6. Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma.
      Title: Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma.
    7. Loss of SARM1 ameliorates secondary thalamic neurodegeneration after cerebral infarction.
      Title: Loss of SARM1 ameliorates secondary thalamic neurodegeneration after cerebral infarction.
    8. SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.
      Title: SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.
    9. Targeting SARM1 improves autophagic stress-induced axonal neuropathy.
      Title: Targeting SARM1 improves autophagic stress-induced axonal neuropathy.
    10. Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
      Title: Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
    Submit: New GeneRIF Correction See all GeneRIFs (83)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ nucleosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADP+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NAD catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse pruning IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to axon injury ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in extrinsic component of synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(+) hydrolase SARM1
    Names
    NADP(+) hydrolase SARM1
    NADase SARM1
    Tir-1 homolog
    sterile alpha and TIR motif containing 1
    sterile alpha and TIR motif-containing protein 1
    NP_001161993.1
    NP_766383.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168521.1 → NP_001161993.1  NAD(+) hydrolase SARM1 isoform 1

      See identical proteins and their annotated locations for NP_001161993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL591177, BC080850, BU704378
      Consensus CDS
      CCDS48857.1
      UniProtKB/TrEMBL
      A0PJL3
      Related
      ENSMUSP00000103922.4, ENSMUST00000108287.10
      Conserved Domains (4) summary
      cd09501
      Location:409 → 477
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:479 → 544
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:409 → 476
      SAM; Sterile alpha motif
      smart00255
      Location:601 → 742
      TIR; Toll - interleukin 1 - resistance

    2. NM_172795.3 → NP_766383.2  NAD(+) hydrolase SARM1 isoform 2

      See identical proteins and their annotated locations for NP_766383.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL591177, BC080850
      Consensus CDS
      CCDS25105.1
      UniProtKB/Swiss-Prot
      Q5SYG5, Q5SYG6, Q6A054, Q6PDS3, Q6SZW0, Q8BRI9
      UniProtKB/TrEMBL
      A0PJL3
      Related
      ENSMUSP00000051059.7, ENSMUST00000061174.7
      Conserved Domains (4) summary
      cd09501
      Location:409 → 477
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:479 → 547
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:409 → 476
      SAM; Sterile alpha motif
      smart00255
      Location:561 → 702
      TIR; Toll - interleukin 1 - resistance

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78361099..78388642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001780001.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDS3.1 GenPept UniProtKB/Swiss-Prot:Q6PDS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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