Gpr151 G protein-coupled receptor 151 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr151provided by MGI
Official Full Name: G protein-coupled receptor 151provided by MGI
Primary source: MGI:MGI:2441887
See related: Ensembl:ENSMUSG00000042816 AllianceGenome:MGI:2441887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGR7; GalRL; nGPCR-2037; C130082O03Rik
Summary: Predicted to enable identical protein binding activity and neuropeptide receptor activity. Involved in regulation of synaptic vesicle exocytosis. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and immune system. Orthologous to human GPR151 (G protein-coupled receptor 151). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 22.71 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (42710946..42712717, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (42577881..42579652, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula.
Title: The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula.
G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gbetagamma/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion.
Title: G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion.
These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability
Title: The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake.
Spinal nerve ligation increased GPR151 expression in the spinal cord and inhibition of GPR151 alleviated neuropathic pain.
Title: Demethylation of G-Protein-Coupled Receptor 151 Promoter Facilitates the Binding of Krüppel-Like Factor 5 and Enhances Neuropathic Pain after Nerve Injury in Mice.
Study presents a map of the afferent connectivity of a diencephalic neuronal population defined by Gpr151 expression. The connectivity of thalamic versus habenular Gpr151-expressing neurons differed substantially, indicating a neuroanatomical heterogeneity within the Gpr151-system.
Title: Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain.
Gpr151 mRNA in the DRG is elevated a model of neuropathic pain. Pain-related behaviour is unchanged is Gpr151 mutants.
Title: Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
This study demonstrated that GPR151 expression in the mouse brain is restricted to habenular neurons projecting to the interpeduncular nucleus,Rostromedial tegmental nucleus, rhabdoid nucleus, mesencephalic raphe nuclei, and dorsal tegmental nucleus.
Title: Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
Galanin-receptor like (GalRL) expression is found in the dorsal thalamus; hybridization signals are detected in the striatum, the locus coeruleus, and several hindbrain nuclei.
Title: Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492347

Gpr151 (e-PCR), detects polymorphism
- UniSTS:532299

Gpr151 (e-PCR), detects polymorphism
- UniSTS:496026

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cholinergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G-protein coupled receptor 151 protein

Names: G-protein coupled receptor PGR7; GPCR-2037; probable G-protein coupled receptor 151 protein; putative G protein-coupled receptor nGPCR-2037

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181543.2 → NP_853521.1 G-protein coupled receptor 151 protein

See identical proteins and their annotated locations for NP_853521.1

Status: VALIDATED

Source sequence(s)

AC121603

Consensus CDS

CCDS29215.1

UniProtKB/Swiss-Prot

Q0VBS2, Q7TSN6, Q80UD8, Q8BX88

Related

ENSMUSP00000058887.4, ENSMUST00000054738.5

Conserved Domains (1) summary

cd15002
Location:42 → 321

7tmA_GPR151; G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors