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    REG2 protein phosphatase regulator REG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852340, updated on 27-Dec-2024

    Summary

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    Official Symbol
    REG2
    Official Full Name
    protein phosphatase regulator REG2
    Primary source
    SGD:S000000254
    Locus tag
    YBR050C
    See related
    AllianceGenome:SGD:S000000254; FungiDB:YBR050C; VEuPathDB:YBR050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase regulator activity. Involved in cellular response to glucose stimulus. Acts upstream of or within regulation of cellular response to glucose starvation. Part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REG2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (337183..338199, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S11B Neighboring gene DNA-binding protein REB1 Neighboring gene flavodoxin-like fold family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of SNF4 and deletions of REG1- and REG2-enhanced maltose metabolism and leavening ability of baker's yeast in lean dough. Lin X, et al. J Ind Microbiol Biotechnol, 2018 Sep. PMID 29936578
    2. The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Frederick DL, et al. Mol Cell Biol, 1996 Jun. PMID 8649403, Free PMC Article
    3. Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae. Maziarz M, et al. Appl Environ Microbiol, 2016 Jul 1. PMID 27107116, Free PMC Article
    4. Protein phosphatase type-1 regulatory subunits Reg1p and Reg2p act as signal transducers in the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. Jiang H, et al. Mol Gen Genet, 2000 Apr. PMID 10821175
    5. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Nigavekar SS, et al. Arch Biochem Biophys, 2002 Aug 1. PMID 12127071

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors present evidence that Reg2 contributes to Snf1 Thr210 dephosphorylation.
      Title: Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein phosphatase type 1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase regulator REG2
    NP_009606.1
    • Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      337183..338199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178398.1 → NP_009606.1  TPA: protein phosphatase regulator REG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009606.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ50, P38232
      UniProtKB/TrEMBL
      G2W956, N1P9D4
      Conserved Domains (1) summary
      pfam08550
      Location:133 → 153
      DUF1752; Fungal protein of unknown function (DUF1752)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38232.1

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