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    SWC5 Swc5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWC5
    Official Full Name
    Swc5p
    Primary source
    SGD:S000000435
    Locus tag
    YBR231C
    See related
    AllianceGenome:SGD:S000000435; FungiDB:YBR231C; VEuPathDB:YBR231C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AOR1
    Summary
    Involved in chromatin remodeling. Located in cytosol and nucleus. Part of Swr1 complex. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWC5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (682179..683090, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Coq21p Neighboring gene ncRNA Neighboring gene Pbp2p Neighboring gene Dad3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells. Mohan C, et al. Elife, 2018 Aug 9. PMID 30091702, Free PMC Article
    2. Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing. Huang Y, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32001508, Free PMC Article
    3. Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B. Chu WT, et al. Proteins, 2021 May. PMID 33320380
    4. Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C. Baier AS, et al. Elife, 2024 May 29. PMID 38809771, Free PMC Article
    5. The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z. Morillo-Huesca M, et al. PLoS One, 2010 Aug 12. PMID 20711347, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
      Title: Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
    2. Swc5 uses a tandem DEF/Y motif facilitate transcription by replacing the two nucleosomal H2A-H2B (A-B) dimers with H2A.Z-H2B (Z-B) dimers.
      Title: Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing.
    3. Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction has been reported.
      Title: Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Swc5p
    NP_009790.3
    • Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      682179..683090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178579.3 → NP_009790.3  TPA: Swc5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009790.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQM7, P38326
      UniProtKB/TrEMBL
      A6ZLH0, C7GMS2, D3UEX8, G2W9N4
      Conserved Domains (1) summary
      pfam07572
      Location:233 → 286
      BCNT; Bucentaur or craniofacial development
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38326.1

    Gene LinkOut

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