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    RTN2 Rtn2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTN2
    Official Full Name
    Rtn2p
    Primary source
    SGD:S000002363
    Locus tag
    YDL204W
    See related
    AllianceGenome:SGD:S000002363; FungiDB:YDL204W; VEuPathDB:YDL204W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ER-dependent peroxisome organization; endoplasmic reticulum organization; and response to endoplasmic reticulum stress. Located in cortical endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTN2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (94605..95786)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene uncharacterized protein Neighboring gene Ack1p Neighboring gene mitochondrial 54S ribosomal protein YmL11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function. Diaz A, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805477, Free PMC Article
    2. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. West M, et al. J Cell Biol, 2011 Apr 18. PMID 21502358, Free PMC Article
    3. High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae. Okamoto M, et al. J Cell Sci, 2012 Jul 15. PMID 22467862
    4. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. Shibata Y, et al. J Biol Chem, 2008 Jul 4. PMID 18442980, Free PMC Article
    5. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Hu J, et al. Science, 2008 Feb 29. PMID 18309084

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Rtn2p
    NP_010077.1
    • Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      94605..95786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180264.1 → NP_010077.1  TPA: Rtn2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF0, Q12443
      UniProtKB/TrEMBL
      B3LH84, C7GV65, G2WBW3, N1PAF0
      Conserved Domains (1) summary
      pfam02453
      Location:33 → 188
      Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12443.1

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