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    Nsg1 neuron specific gene family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18196, updated on 4-Jan-2025

    Summary

    Official Symbol
    Nsg1provided by MGI
    Official Full Name
    neuron specific gene family member 1provided by MGI
    Primary source
    MGI:MGI:109149
    See related
    Ensembl:ENSMUSG00000029126 AllianceGenome:MGI:109149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p21; m234; Neep21
    Summary
    Predicted to enable clathrin light chain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including amyloid precursor protein metabolic process; neurotransmitter receptor transport; and receptor recycling. Located in late endosome; lateral plasma membrane; and postsynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human NSG1 (neuronal vesicle trafficking associated 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in CNS E18 (RPKM 286.0), cerebellum adult (RPKM 209.6) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Nsg1 in Genome Data Viewer
    Location:
    5 B3; 5 20.21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38294537..38317087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38137193..38159743, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12911 Neighboring gene STARR-seq mESC enhancer starr_12912 Neighboring gene predicted gene, 54328 Neighboring gene VISTA enhancer mm429 Neighboring gene predicted gene, 40289 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38414144-38414444 Neighboring gene syntaxin 18 Neighboring gene VISTA enhancer mm1165 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38602912-38603212 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene Ly1 antibody reactive clone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin light chain binding  
    enables clathrin light chain binding  
    enables ionotropic glutamate receptor binding  
    enables ionotropic glutamate receptor binding  
    enables protein binding PubMed 
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in amyloid precursor protein metabolic process PubMed 
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in clathrin coat assembly  
    involved_in clathrin coat assembly  
    involved_in endosomal transport  
    involved_in endosomal transport  
    involved_in neurotransmitter receptor cycle PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane PubMed 
    involved_in positive regulation of receptor recycling  
    involved_in positive regulation of receptor recycling  
    involved_in postsynaptic neurotransmitter receptor cycle  
    involved_in postsynaptic neurotransmitter receptor cycle  
    involved_in receptor recycling PubMed 
    involved_in regulation of long-term synaptic potentiation  
    involved_in regulation of long-term synaptic potentiation  
    involved_in spontaneous synaptic transmission  
    involved_in spontaneous synaptic transmission  
    involved_in vesicle-mediated transport in synapse PubMed 
    involved_in vesicle-mediated transport in synapse PubMed 
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane  
    located_in dendrite  
    located_in dendrite  
    located_in early endosome  
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in endosome  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in late endosome PubMed 
    located_in late endosome  
    located_in late endosome  
    located_in lateral plasma membrane PubMed 
    located_in lysosomal lumen  
    located_in lysosomal lumen  
    is_active_in membrane  
    located_in multivesicular body membrane  
    located_in postsynaptic endosome  
    is_active_in postsynaptic endosome  
    located_in postsynaptic endosome  
    located_in postsynaptic membrane PubMed 
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in somatodendritic compartment  
    located_in somatodendritic compartment  
    located_in trans-Golgi network membrane  
    located_in trans-Golgi network membrane  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    neuronal vesicle trafficking-associated protein 1
    Names
    brain neuron cytoplasmic protein 1
    neuron-enriched endosomal protein of 21 kDa
    neuron-specific protein family member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359090.1NP_001346019.1  neuronal vesicle trafficking-associated protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AC115931
      Consensus CDS
      CCDS19251.1
      UniProtKB/Swiss-Prot
      O54717, Q3UF63, Q62092, Q922E5
      UniProtKB/TrEMBL
      Q8C5M2
      Conserved Domains (1) summary
      pfam06387
      Location:1180
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)
    2. NM_001359091.1NP_001346020.1  neuronal vesicle trafficking-associated protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC115931
      Consensus CDS
      CCDS19251.1
      UniProtKB/Swiss-Prot
      O54717, Q3UF63, Q62092, Q922E5
      UniProtKB/TrEMBL
      Q8C5M2
      Conserved Domains (1) summary
      pfam06387
      Location:1180
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)
    3. NM_001359092.1NP_001346021.1  neuronal vesicle trafficking-associated protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC115931
      Consensus CDS
      CCDS19251.1
      UniProtKB/Swiss-Prot
      O54717, Q3UF63, Q62092, Q922E5
      UniProtKB/TrEMBL
      Q8C5M2
      Related
      ENSMUSP00000144396.2, ENSMUST00000201363.4
      Conserved Domains (1) summary
      pfam06387
      Location:1180
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)
    4. NM_010942.4NP_035072.2  neuronal vesicle trafficking-associated protein 1

      See identical proteins and their annotated locations for NP_035072.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC115931, AK076451, AK148941
      Consensus CDS
      CCDS19251.1
      UniProtKB/Swiss-Prot
      O54717, Q3UF63, Q62092, Q922E5
      UniProtKB/TrEMBL
      Q8C5M2
      Related
      ENSMUSP00000031009.5, ENSMUST00000031009.8
      Conserved Domains (1) summary
      pfam06387
      Location:1180
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      38294537..38317087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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