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    AAR2 U5 snRNP complex subunit AAR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852205, updated on 4-Jan-2025

    Summary

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    Official Symbol
    AAR2
    Official Full Name
    U5 snRNP complex subunit AAR2
    Primary source
    SGD:S000000170
    Locus tag
    YBL074C
    See related
    AllianceGenome:SGD:S000000170; FungiDB:YBL074C; VEuPathDB:YBL074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in spliceosomal tri-snRNP complex assembly. Part of U5 snRNP. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See AAR2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (86722..87789, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene isoleucine--tRNA ligase ILS1 Neighboring gene Hsp70 family ATPase SSA3 Neighboring gene ncRNA Neighboring gene ribosomal 40S subunit protein S8A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aar2p regulates both protein and RNA binding to Prp8p during U5 snRNP assembly
      Title: Structural basis for dual roles of Aar2p in U5 snRNP assembly.
    2. Prp8 interaction sites with Aar2 protein
      Title: Prp8p dissection reveals domain structure and protein interaction sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U5 snRNP complex subunit AAR2
    NP_009479.1
    • Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      86722..87789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178314.1 → NP_009479.1  TPA: U5 snRNP complex subunit AAR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPS8, P32357
      UniProtKB/TrEMBL
      A6ZKM7, B3LNK7, B5VDR6, C7GK59, C8Z3R9, G2W8T7, N1P8G2
      Conserved Domains (2) summary
      cd13778
      Location:175 → 313
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:3 → 283
      AAR2; AAR2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32357.1

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