PHO12 acid phosphatase PHO12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHO12
Official Full Name: acid phosphatase PHO12
Primary source: SGD:S000001258
Locus tag: YHR215W
See related: AllianceGenome:SGD:S000001258; FungiDB:YHR215W; VEuPathDB:YHR215W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PHO10
Summary: Enables acid phosphatase activity. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PHO12 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (552099..553502)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: acid phosphatase PHO12

NP_012087.1

EC 3.1.3.2

One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

552099..553502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179346.1 → NP_012087.1 TPA: acid phosphatase PHO12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012087.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLH0, P38693

UniProtKB/TrEMBL

A6ZSK5, B3LUF9, B5VKE4, C7GJR1, C8Z7M5, N1P2L2

Conserved Domains (1) summary

pfam00328
Location:65 → 399

His_Phos_2; Histidine phosphatase superfamily (branch 2)