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    ITR2 myo-inositol transporter ITR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ITR2
    Official Full Name
    myo-inositol transporter ITR2
    Primary source
    SGD:S000005463
    Locus tag
    YOL103W
    See related
    AllianceGenome:SGD:S000005463; FungiDB:YOL103W; VEuPathDB:YOL103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRB612
    Summary
    Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport. Located in plasma membrane. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ITR2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (124001..125830)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ndj1p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene Izh4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production and reutilization of an extracellular phosphatidylinositol catabolite, glycerophosphoinositol, by Saccharomyces cerevisiae. Patton JL, et al. J Bacteriol, 1995 Jun. PMID 7768846, Free PMC Article
    2. Mutational analysis and localization of the inositol transporters of Saccharomyces cerevisiae. Miyashita M, et al. J Biosci Bioeng, 2003. PMID 16233524
    3. Two major inositol transporters and their role in cryptococcal virulence. Wang Y, et al. Eukaryot Cell, 2011 May. PMID 21398509, Free PMC Article
    4. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Xue C, et al. mBio, 2010 May 18. PMID 20689743, Free PMC Article
    5. Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Nikawa J, et al. Mol Microbiol, 1993 Dec. PMID 7934871

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myo-inositol transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables myo-inositol:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in myo-inositol import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myo-inositol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myo-inositol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myo-inositol transporter ITR2
    NP_014538.2
    • Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      124001..125830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183357.1 → NP_014538.2  TPA: myo-inositol transporter ITR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014538.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1W5, P30606
      UniProtKB/TrEMBL
      A6ZNA6, B3LIW1, B5VRF1, C7GRV5, C8ZHL1, G2WMD2, N1NZ29
      Conserved Domains (1) summary
      cd17360
      Location:115 → 556
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30606.2

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