U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [ Mus musculus (house mouse) ]

    Gene ID: 19248, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpn12provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 12provided by MGI
    Primary source
    MGI:MGI:104673
    See related
    Ensembl:ENSMUSG00000028771 AllianceGenome:MGI:104673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTPG1; P19-PTP; PTP-P19; PTP-PEST
    Summary
    Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in cytosol and podosome. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; gut; and retina. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.7), CNS E18 (RPKM 8.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptpn12 in Genome Data Viewer
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21191643..21261009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (20986645..21055911, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12554 Neighboring gene transmembrane protein 60 Neighboring gene round spermatid basic protein 1-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:20447096-20447297 Neighboring gene STARR-seq mESC enhancer starr_12555 Neighboring gene RIKEN cDNA A630072M18 gene Neighboring gene STARR-seq mESC enhancer starr_12556 Neighboring gene STARR-seq mESC enhancer starr_12557 Neighboring gene STARR-seq mESC enhancer starr_12559 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20484581-20484882 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20508606-20508906 Neighboring gene STARR-positive B cell enhancer ABC_E10306 Neighboring gene STARR-seq mESC enhancer starr_12560 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20561662-20561962 Neighboring gene STARR-seq mESC enhancer starr_12561 Neighboring gene predicted gene, 42221 Neighboring gene predicted gene, 22490

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 12
    Names
    MPTP-PEST
    protein-tyrosine phosphatase P19
    NP_001343519.1
    NP_001343520.1
    NP_001343521.1
    NP_001411448.1
    NP_001411450.1
    NP_035333.2
    XP_030110077.1
    XP_036020804.1
    XP_036020805.1
    XP_036020806.1
    XP_036020807.1
    XP_036020808.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356590.1NP_001343519.1  tyrosine-protein phosphatase non-receptor type 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:43312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. NM_001356591.2NP_001343520.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:1179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. NM_001356592.1NP_001343521.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:1179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    4. NM_001424519.1NP_001411448.1  tyrosine-protein phosphatase non-receptor type 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116501, AC121572
    5. NM_001424521.1NP_001411450.1  tyrosine-protein phosphatase non-receptor type 12 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116501, AC121572
    6. NM_011203.4NP_035333.2  tyrosine-protein phosphatase non-receptor type 12 isoform b

      See identical proteins and their annotated locations for NP_035333.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC116501, AC121572
      Consensus CDS
      CCDS19102.1
      UniProtKB/Swiss-Prot
      P35831, Q80UM4
      Related
      ENSMUSP00000030556.8, ENSMUST00000030556.8
      Conserved Domains (2) summary
      smart00194
      Location:28292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21191643..21261009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164914.1XP_036020807.1  tyrosine-protein phosphatase non-receptor type 12 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:1179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_036164915.1XP_036020808.1  tyrosine-protein phosphatase non-receptor type 12 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:187
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_036164912.1XP_036020805.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

      Conserved Domains (1) summary
      cl28904
      Location:43312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    4. XM_036164911.1XP_036020804.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:43312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    5. XM_036164913.1XP_036020806.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    6. XM_030254217.2XP_030110077.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_004942461.1 RNA Sequence

    2. XR_004942460.1 RNA Sequence