Kif26a kinesin family member 26A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif26aprovided by MGI
Official Full Name: kinesin family member 26Aprovided by MGI
Primary source: MGI:MGI:2447072
See related: Ensembl:ENSMUSG00000021294 AllianceGenome:MGI:2447072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1236
Summary: Enables microtubule binding activity. Involved in enteric nervous system development; negative regulation of signal transduction; and regulation of cell growth by extracellular stimulus. Predicted to be located in cytoplasm and microtubule. Is expressed in central nervous system; ganglia; and intestine. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 14.0), whole brain E14.5 (RPKM 13.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.14 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (112109378..112148181)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (112143974..112181747)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
Title: KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
Title: Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
Title: Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling
Title: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

Kif26a (e-PCR), detects polymorphism
- UniSTS:548043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth by extracellular stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF26A

Names: N-11 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097621.1 → NP_001091090.1 kinesin-like protein KIF26A

See identical proteins and their annotated locations for NP_001091090.1

Status: VALIDATED

Source sequence(s)

BC059062, BC094358, BM963109, CB518589, CB520233, CD348409, CD350871, CD352284, CJ130134

Consensus CDS

CCDS49186.1

UniProtKB/Swiss-Prot

C9EF47, Q52KG5, Q6PCY3, Q6ZPV4, Q99PT4

Related

ENSMUSP00000119482.2, ENSMUST00000128402.3

Conserved Domains (2) summary

smart00129
Location:365 → 725

KISc; Kinesin motor, catalytic domain. ATPase

cd00106
Location:364 → 716

KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

112109378..112148181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516162.4 → XP_006516225.1 kinesin-like protein KIF26A isoform X1

Conserved Domains (3) summary

PHA03247
Location:1154 → 1647

PHA03247; large tegument protein UL36; Provisional

PRK07764
Location:869 → 1301

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00106
Location:396 → 748

KISc; Kinesin motor domain
XM_036157581.1 → XP_036013474.1 kinesin-like protein KIF26A isoform X2

Conserved Domains (3) summary

PHA03247
Location:860 → 1353

PHA03247; large tegument protein UL36; Provisional

PRK07764
Location:575 → 1007

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00106
Location:102 → 454

KISc; Kinesin motor domain