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    TRM10 tRNA (guanine(9)-N(1))-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRM10
    Official Full Name
    tRNA (guanine(9)-N(1))-methyltransferase
    Primary source
    SGD:S000005453
    Locus tag
    YOL093W
    See related
    AllianceGenome:SGD:S000005453; FungiDB:YOL093W; VEuPathDB:YOL093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine) methyltransferase activity. Involved in tRNA methylation. Located in cytoplasm and nucleus. Used to study glucose metabolism disease; intellectual disability; and microcephaly. Orthologous to human TRMT10A (tRNA methyltransferase 10A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRM10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (142815..143696)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene replication factor C subunit 4 Neighboring gene cationic amino acid transporter Neighboring gene Spo21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A tRNA-specific function for tRNA methyltransferase Trm10 is associated with a new tRNA quality control mechanism in Saccharomyces cerevisiae. Bowles IE, et al. RNA, 2024 Jan 16. PMID 38071471,
    2. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. Jackman JE, et al. RNA, 2003 May. PMID 12702816, Free PMC Article
    3. tRNA m(1)G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10. Strassler SE, et al. J Biol Chem, 2023 Dec. PMID 37949221, Free PMC Article
    4. An mRNA-derived noncoding RNA targets and regulates the ribosome. Pircher A, et al. Mol Cell, 2014 Apr 10. PMID 24685157, Free PMC Article
    5. Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10. Krishnamohan A, et al. Nucleic Acids Res, 2017 Sep 6. PMID 28911116, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tRNA m[1]G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
      Title: tRNA m(1)G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
    2. A tRNA-specific function for tRNA methyltransferase Trm10 is associated with a new tRNA quality control mechanism in Saccharomyces cerevisiae.
      Title: A tRNA-specific function for tRNA methyltransferase Trm10 is associated with a new tRNA quality control mechanism in Saccharomyces cerevisiae.
    3. Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10, has been reported.
      Title: Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10.
    4. The findings revealed that Trm10 is a new member of the SpoU-TrmD (SPOUT) MTase superfamily.
      Title: Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
    5. The in vitro methylation activity of Trm10 is not sufficient to explain the observed pattern of modification in vivo, as additional tRNA species are substrates for Trm10 m1G9 methyltransferase activity.
      Title: Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10.
    6. Our results also provide genetic evidence for a new role of Trm10p in translation termination efficiency.
      Title: Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine) methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanosine(9)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(9)-N(1))-methyltransferase
    NP_014548.1
    • tRNA methyltransferase; methylates the N-1 of guanine at position 9 in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer ncRNA originates from the TRM10 locus; genetic analysis shows the 18-mer ncRNA is a translational regulator; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      142815..143696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183347.1 → NP_014548.1  TPA: tRNA (guanine(9)-N(1))-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X5, Q12400
      UniProtKB/TrEMBL
      A6ZNB7, G2WME2, N1NZ37
      Conserved Domains (1) summary
      cd18089
      Location:97 → 271
      SPOUT_Trm10-like; tRNA methyltransferase Trm10-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12400.1

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