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    Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [ Mus musculus (house mouse) ]

    Gene ID: 20348, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sema3cprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Cprovided by MGI
    Primary source
    MGI:MGI:107557
    See related
    Ensembl:ENSMUSG00000028780 AllianceGenome:MGI:107557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SemE; Semae; 1110036B02Rik
    Summary
    Enables semaphorin receptor binding activity. Involved in several processes, including cardiac endothelial to mesenchymal transition; chordate embryonic development; and circulatory system development. Acts upstream of or within several processes, including blood vessel remodeling; dichotomous subdivision of terminal units involved in salivary gland branching; and neural crest cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 26.3), lung adult (RPKM 25.9) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sema3c in Genome Data Viewer
    Location:
    5 A3; 5 7.99 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (17779814..17935266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (17574816..17730268)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 31555 Neighboring gene STARR-seq mESC enhancer starr_12499 Neighboring gene STARR-positive B cell enhancer mm9_chr5:17322004-17322304 Neighboring gene CD36 molecule Neighboring gene STARR-positive B cell enhancer ABC_E6307 Neighboring gene STARR-positive B cell enhancer ABC_E8043 Neighboring gene predicted gene, 31612

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac endothelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac right ventricle morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb bud formation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in outflow tract morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pulmonary myocardium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somitogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    semaphorin-3C
    Names
    sema E
    semaphorin E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013657.5NP_038685.3  semaphorin-3C precursor

      See identical proteins and their annotated locations for NP_038685.3

      Status: PROVISIONAL

      Source sequence(s)
      AC122936, AC161507
      Consensus CDS
      CCDS19099.1
      UniProtKB/Swiss-Prot
      Q62181, Q6NXW7
      Related
      ENSMUSP00000030568.8, ENSMUST00000030568.14
      Conserved Domains (4) summary
      cd05871
      Location:575664
      Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
      cd11251
      Location:45514
      Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)
      smart00410
      Location:579653
      IG_like; Immunoglobulin like
      smart00423
      Location:513550
      PSI; domain found in Plexins, Semaphorins and Integrins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      17779814..17935266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)