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    Foxb2 forkhead box B2 [ Mus musculus (house mouse) ]

    Gene ID: 14240, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxb2provided by MGI
    Official Full Name
    forkhead box B2provided by MGI
    Primary source
    MGI:MGI:1347468
    See related
    Ensembl:ENSMUSG00000056829 AllianceGenome:MGI:1347468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fkh4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; nervous system; and sensory organ. Orthologous to human FOXB2 (forkhead box B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Foxb2 in Genome Data Viewer
    Location:
    19 B; 19 12.26 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16849680..16851194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16872316..16873830, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha 14 Neighboring gene predicted gene, 41811 Neighboring gene STARR-seq mESC enhancer starr_45666 Neighboring gene vacuolar protein sorting 13A Neighboring gene predicted gene, 32256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:16855612-16855721 Neighboring gene STARR-seq mESC enhancer starr_45668 Neighboring gene predicted gene, 32341 Neighboring gene STARR-seq mESC enhancer starr_45670 Neighboring gene STARR-seq mESC enhancer starr_45671 Neighboring gene prune homolog 2 Neighboring gene STARR-seq mESC enhancer starr_45673 Neighboring gene STARR-seq mESC enhancer starr_45676

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    forkhead box protein B2
    Names
    forkhead homolog 4
    transcription factor FKH-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008023.2NP_032049.1  forkhead box protein B2

      See identical proteins and their annotated locations for NP_032049.1

      Status: VALIDATED

      Source sequence(s)
      AC125185
      Consensus CDS
      CCDS29686.1
      UniProtKB/Swiss-Prot
      Q64733
      UniProtKB/TrEMBL
      B9EII5
      Related
      ENSMUSP00000072687.3, ENSMUST00000072915.4
      Conserved Domains (2) summary
      smart00339
      Location:13101
      FH; FORKHEAD
      pfam06752
      Location:342406
      E_Pc_C; Enhancer of Polycomb C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      16849680..16851194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)