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    Gnai1 G protein subunit alpha i1 [ Mus musculus (house mouse) ]

    Gene ID: 14677, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gnai1provided by MGI
    Official Full Name
    G protein subunit alpha i1provided by MGI
    Primary source
    MGI:MGI:95771
    See related
    Ensembl:ENSMUSG00000057614 AllianceGenome:MGI:95771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg1b; Gnai-1; Gialpha1
    Summary
    Predicted to enable several functions, including G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including cellular response to forskolin; positive regulation of protein localization to cell cortex; and regulation of cAMP-mediated signaling. Predicted to be located in several cellular components, including centrosome; midbody; and nuclear lumen. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; forelimb; gut; nervous system; and reproductive system. Orthologous to human GNAI1 (G protein subunit alpha i1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 36.7), cerebellum adult (RPKM 28.5) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gnai1 in Genome Data Viewer
    Location:
    5 A3; 5 8.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (18470133..18565411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (18265135..18360413, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9632 Neighboring gene STARR-seq mESC enhancer starr_12500 Neighboring gene predicted gene, 31612 Neighboring gene STARR-positive B cell enhancer mm9_chr5:17515822-17516123 Neighboring gene STARR-positive B cell enhancer ABC_E2153 Neighboring gene STARR-seq mESC enhancer starr_12501 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene predicted gene, 54321 Neighboring gene STARR-seq mESC enhancer starr_12503 Neighboring gene STARR-seq mESC enhancer starr_12504 Neighboring gene STARR-seq mESC enhancer starr_12507 Neighboring gene STARR-seq mESC enhancer starr_12508 Neighboring gene STARR-seq mESC enhancer starr_12509 Neighboring gene STARR-seq mESC enhancer starr_12510 Neighboring gene STARR-seq mESC enhancer starr_12511 Neighboring gene predicted gene 3527 Neighboring gene STARR-seq mESC enhancer starr_12512 Neighboring gene predicted gene, 31752 Neighboring gene STARR-seq mESC enhancer starr_12513 Neighboring gene STARR-seq mESC enhancer starr_12514 Neighboring gene STARR-seq mESC enhancer starr_12515 Neighboring gene STARR-seq mESC enhancer starr_12517 Neighboring gene STARR-seq mESC enhancer starr_12519 Neighboring gene STARR-seq mESC enhancer starr_12521 Neighboring gene transketolase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D2 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D2 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled serotonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables adenylate cyclase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to forskolin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to prostaglandin E IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(i) subunit alpha-1
    Names
    adenylate cyclase-inhibiting G alpha protein
    guanine nucleotide binding protein (G protein), alpha inhibiting 1
    guanine nucleotide binding protein, alpha inhibiting 1
    heterotrimeric guanine nucleotide-binding protein 1b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010305.1NP_034435.1  guanine nucleotide-binding protein G(i) subunit alpha-1

      See identical proteins and their annotated locations for NP_034435.1

      Status: VALIDATED

      Source sequence(s)
      AC116505, BC032995, BY740128
      Consensus CDS
      CCDS39018.1
      UniProtKB/Swiss-Prot
      B2RSH2
      UniProtKB/TrEMBL
      Q3TJH1
      Related
      ENSMUSP00000074259.6, ENSMUST00000074694.7
      Conserved Domains (1) summary
      cd00066
      Location:34348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      18470133..18565411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)