Bsg basigin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bsgprovided by MGI
Official Full Name: basiginprovided by MGI
Primary source: MGI:MGI:88208
See related: Ensembl:ENSMUSG00000023175 AllianceGenome:MGI:88208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HT-7; CD147; EMMPRIN
Summary: Predicted to enable cell-cell adhesion mediator activity; signaling receptor activity; and virus receptor activity. Involved in neural retina development; photoreceptor cell maintenance; and spermatogenesis. Located in several cellular components, including acrosomal membrane; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and reproductive system. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 307.0), placenta adult (RPKM 296.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79540192..79547813)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79704358..79711979)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.
Title: CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.
Title: CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.
EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells.
Title: EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells.
CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis.
Title: CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis.
High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-alpha.
Title: High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-α.
Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice.
Title: Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice.
S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
Title: S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
Full activation of thermogenesis in brown adipocytes requires Basigin action.
Title: Full activation of thermogenesis in brown adipocytes requires Basigin action.
Reduced expression of Basigin gene products in response to chronic inflammation may contribute to vision loss.
Title: Reduced expression of Basigin gene products in response to chronic inflammation may contribute to vision loss.
CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.
Title: CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (108)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325119 (e-PCR)
- UniSTS:165706

Bsg (e-PCR), detects polymorphism
- UniSTS:461903

Bsg (e-PCR), detects polymorphism
- UniSTS:461904

Bsg (e-PCR), detects polymorphism
- UniSTS:265615

Bsg (e-PCR), detects polymorphism
- UniSTS:527272

RH135862 (e-PCR)
- UniSTS:209860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IEA Inferred from Electronic Annotation more info
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in decidualization	IEA Inferred from Electronic Annotation more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to mercury ion	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: basigin

Names: 5A11/Basigin; HT7 antigen; basic immunoglobulin superfamily; gp 42; membrane glycoprotein gp42; neurothelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077184.1 → NP_001070652.1 basigin isoform 2 precursor

See identical proteins and their annotated locations for NP_001070652.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.

Source sequence(s)

AC151828, AK002332

Consensus CDS

CCDS35967.1

UniProtKB/TrEMBL

O55107

Related

ENSMUSP00000136487.2, ENSMUST00000179781.8

Conserved Domains (2) summary

cd00096
Location:122 → 203

Ig; Immunoglobulin domain

smart00410
Location:117 → 206

IG_like; Immunoglobulin like
NM_009768.2 → NP_033898.1 basigin isoform 1 precursor

See identical proteins and their annotated locations for NP_033898.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC151828, AY089967

Consensus CDS

CCDS23985.1

UniProtKB/Swiss-Prot

P18572, Q6LDB0, Q7TSC0

Related

ENSMUSP00000070751.6, ENSMUST00000067036.12

Conserved Domains (3) summary

cd00096
Location:238 → 319

Ig; Immunoglobulin domain

smart00410
Location:233 → 322

IG_like; Immunoglobulin like

pfam00047
Location:27 → 111

ig; Immunoglobulin domain