Bsph1 binder of sperm protein homolog 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bsph1provided by MGI
Official Full Name: binder of sperm protein homolog 1provided by MGI
Primary source: MGI:MGI:2685613
See related: Ensembl:ENSMUSG00000074378 AllianceGenome:MGI:2685613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm767
Summary: This gene encodes a member of the binder of sperm family. The encoded protein may be involved in sperm capacitation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Restricted expression toward genital fat pad adult (RPKM 5.1) See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (13184766..13207375)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (13450841..13473450)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.
Title: Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.
Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse sperm-egg interaction and fertilization.
Title: Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse sperm-egg interaction and fertilization.
Both native BSPH1 and recombinant-BSPH1 were detected on the head and the midpiece region of sperm, although a stronger signal was detected on the midpiece region when sperm were incubated in a capacitating media.
Title: Characterization of recombinant murine binder of sperm protein homolog 1 and its role in capacitation.
Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related.
Title: Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: binder of sperm protein homolog 1

Names: bovine seminal plasma protein homolog 1; bovine seminal plasma protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033418.4 → NP_001028590.1 binder of sperm protein homolog 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001028590.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC156985, AK136662, BB073190

Consensus CDS

CCDS20832.1

UniProtKB/Swiss-Prot

B2RVZ6, Q3UW26

Related

ENSMUSP00000096408.2, ENSMUST00000098811.4

Conserved Domains (1) summary

pfam00040
Location:90 → 131

fn2; Fibronectin type II domain
NM_001301682.1 → NP_001288611.1 binder of sperm protein homolog 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001288611.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC156985, AK136662, BB073190

Consensus CDS

CCDS85218.1

UniProtKB/TrEMBL

B7ZWD1

Related

ENSMUSP00000144997.2, ENSMUST00000204715.2

Conserved Domains (1) summary

pfam00040
Location:80 → 121

fn2; Fibronectin type II domain