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    Gabpb1 GA repeat binding protein, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabpb1provided by MGI
    Official Full Name
    GA repeat binding protein, beta 1provided by MGI
    Primary source
    MGI:MGI:95611
    See related
    Ensembl:ENSMUSG00000027361 AllianceGenome:MGI:95611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E4TF1; GABPB; BABPB2; E4Tf1B; NRF2B1; NRF2B2; GABPB-1; GABPB-2; E4TF1-47; E4TF1-53; GABPB1-1; GABPB1-2
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Involved in mitochondrion organization. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Orthologous to human GABPB1 (GA binding protein transcription factor subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), limb E14.5 (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gabpb1 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126470832..126527184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126628907..126684435, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11157 Neighboring gene histidine decarboxylase Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene RIKEN cDNA A630026N12 gene Neighboring gene STARR-seq mESC enhancer starr_05607 Neighboring gene STARR-seq mESC enhancer starr_05610 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of alternative transcripts of the mouse GA-binding protein (Gabp) subunits alpha and beta1. O'Leary DA, et al. Gene, 2005 Jan 3. PMID 15656975
    2. Identification of Ets- and notch-related subunits in GA binding protein. LaMarco K, et al. Science, 1991 Aug 16. PMID 1876836
    3. Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos. Ihashi S, et al. Life Sci Alliance, 2023 Nov. PMID 37640449, Free PMC Article
    4. Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation. Hashiguchi M, et al. Immunol Lett, 2011 Dec 30. PMID 21944889
    5. Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells. Yu S, et al. Cell Stem Cell, 2012 Aug 3. PMID 22862946, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos.
      Title: Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos.
    2. SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1.
      Title: A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.
    3. The findings identify the tetramer-forming GABPbeta1 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy.
      Title: Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.
    4. After antigenic stimulation CD4+/CD62Lhigh cells from Peyer's patches express a greater amount of transcripts of GA-binding protein beta subunit 1 than those from the spleen.
      Title: Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.
    5. GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex.
      Title: Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GA-binding protein subunit beta-1
    Names
    GA binding protein subunit beta1
    GABP subunit beta-1
    GABP subunit beta-2
    Gabp beta1
    NP_001258396.1
    NP_001258397.1
    NP_001258398.1
    NP_001258399.1
    NP_001258421.1
    NP_001342037.1
    NP_001342038.1
    NP_001393121.1
    NP_001393122.1
    NP_001393123.1
    NP_001393124.1
    NP_001393125.1
    NP_001393126.1
    NP_001393127.1
    NP_001393128.1
    NP_001393129.1
    NP_001393130.1
    NP_001393131.1
    NP_001393132.1
    NP_001393133.1
    NP_001393134.1
    NP_001393135.1
    NP_001393136.1
    NP_001393137.1
    NP_001393138.1
    NP_001393139.1
    NP_001393140.1
    NP_001393141.1
    NP_001393142.1
    NP_001393143.1
    NP_001393144.1
    NP_001393145.1
    NP_001393146.1
    NP_001393147.1
    NP_001393148.1
    NP_001393149.1
    NP_001393150.1
    NP_001393151.1
    NP_001393152.1
    NP_001393153.1
    NP_001393154.1
    NP_001393155.1
    NP_001393156.1
    NP_034379.1
    NP_997552.1
    XP_006498819.1
    XP_006498824.1
    XP_030103388.1
    XP_036014243.1
    XP_036014249.1
    XP_036014264.1
    XP_036014265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271467.2 → NP_001258396.1  GA-binding protein subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_001258396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform (a).
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS16685.1
      UniProtKB/TrEMBL
      Q3UJN3, Q3US22
      Related
      ENSMUSP00000099517.2, ENSMUST00000103227.8
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315 → 369
      Oberon_cc; Coiled-coil region of Oberon

    2. NM_001271468.2 → NP_001258397.1  GA-binding protein subunit beta-1 isoform d

      See identical proteins and their annotated locations for NP_001258397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform d which has one additional amino acid compared to isoform a.
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS71137.1
      UniProtKB/Swiss-Prot
      A2AQ68, A2AQ70, Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2
      UniProtKB/TrEMBL
      Q3UJN3
      Related
      ENSMUSP00000106055.3, ENSMUST00000110425.9
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316 → 370
      Oberon_cc; Coiled-coil region of Oberon

    3. NM_001271469.2 → NP_001258398.1  GA-binding protein subunit beta-1 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks several alternate in-frame exons in the coding region compared to variant 1. The resulting protein (isoform f) uses the same start codon but is shorter than isoform a. PubMed ID: 15656975 suggests that this protein lacks a nuclear localization signal found in isoform a.
      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ10
      Conserved Domains (2) summary
      sd00045
      Location:10 → 35
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10 → 92
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001271470.2 → NP_001258399.1  GA-binding protein subunit beta-1 isoform e

      See identical proteins and their annotated locations for NP_001258399.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS71136.1
      UniProtKB/TrEMBL
      Q3UJN3, Q3UT69
      Related
      ENSMUSP00000037673.7, ENSMUST00000039978.13
      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    5. NM_001271492.1 → NP_001258421.1  GA-binding protein subunit beta-1 isoform c

      See identical proteins and their annotated locations for NP_001258421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK040722, AL844555
      Consensus CDS
      CCDS71135.1
      UniProtKB/Swiss-Prot
      Q00420
      Related
      ENSMUSP00000087177.5, ENSMUST00000089745.11
      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    6. NM_001355108.2 → NP_001342037.1  GA-binding protein subunit beta-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3
      Conserved Domains (3) summary
      sd00045
      Location:10 → 35
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10 → 92
      Ank_2; Ankyrin repeats (3 copies)
      cl03075
      Location:259 → 306
      GrpE; nucleotide exchange factor GrpE

    7. NM_001355109.2 → NP_001342038.1  GA-binding protein subunit beta-1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL844555
      Conserved Domains (2) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    8. NM_001406192.1 → NP_001393121.1  GA-binding protein subunit beta-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3, Q3US22

    9. NM_001406193.1 → NP_001393122.1  GA-binding protein subunit beta-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    10. NM_001406194.1 → NP_001393123.1  GA-binding protein subunit beta-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    11. NM_001406195.1 → NP_001393124.1  GA-binding protein subunit beta-1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    12. NM_001406196.1 → NP_001393125.1  GA-binding protein subunit beta-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    13. NM_001406197.1 → NP_001393126.1  GA-binding protein subunit beta-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/Swiss-Prot
      A2AQ68, A2AQ70, Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2
      UniProtKB/TrEMBL
      Q3UJN3

    14. NM_001406198.1 → NP_001393127.1  GA-binding protein subunit beta-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/Swiss-Prot
      A2AQ68, A2AQ70, Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2
      UniProtKB/TrEMBL
      Q3UJN3

    15. NM_001406199.1 → NP_001393128.1  GA-binding protein subunit beta-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/Swiss-Prot
      A2AQ68, A2AQ70, Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2
      UniProtKB/TrEMBL
      Q3UJN3

    16. NM_001406200.1 → NP_001393129.1  GA-binding protein subunit beta-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/Swiss-Prot
      A2AQ68, A2AQ70, Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2
      UniProtKB/TrEMBL
      Q3UJN3

    17. NM_001406201.1 → NP_001393130.1  GA-binding protein subunit beta-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3, Q3UT69

    18. NM_001406202.1 → NP_001393131.1  GA-binding protein subunit beta-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3, Q3UT69

    19. NM_001406203.1 → NP_001393132.1  GA-binding protein subunit beta-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    20. NM_001406204.1 → NP_001393133.1  GA-binding protein subunit beta-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    21. NM_001406205.1 → NP_001393134.1  GA-binding protein subunit beta-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    22. NM_001406206.1 → NP_001393135.1  GA-binding protein subunit beta-1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL844555

    23. NM_001406207.1 → NP_001393136.1  GA-binding protein subunit beta-1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    24. NM_001406208.1 → NP_001393137.1  GA-binding protein subunit beta-1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    25. NM_001406209.1 → NP_001393138.1  GA-binding protein subunit beta-1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    26. NM_001406210.1 → NP_001393139.1  GA-binding protein subunit beta-1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    27. NM_001406211.1 → NP_001393140.1  GA-binding protein subunit beta-1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    28. NM_001406212.1 → NP_001393141.1  GA-binding protein subunit beta-1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    29. NM_001406213.1 → NP_001393142.1  GA-binding protein subunit beta-1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    30. NM_001406214.1 → NP_001393143.1  GA-binding protein subunit beta-1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    31. NM_001406215.1 → NP_001393144.1  GA-binding protein subunit beta-1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    32. NM_001406216.1 → NP_001393145.1  GA-binding protein subunit beta-1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    33. NM_001406217.1 → NP_001393146.1  GA-binding protein subunit beta-1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    34. NM_001406218.1 → NP_001393147.1  GA-binding protein subunit beta-1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q3UJN3

    35. NM_001406219.1 → NP_001393148.1  GA-binding protein subunit beta-1 isoform r

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ09

    36. NM_001406220.1 → NP_001393149.1  GA-binding protein subunit beta-1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ09

    37. NM_001406221.1 → NP_001393150.1  GA-binding protein subunit beta-1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ09

    38. NM_001406222.1 → NP_001393151.1  GA-binding protein subunit beta-1 isoform t

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ08

    39. NM_001406223.1 → NP_001393152.1  GA-binding protein subunit beta-1 isoform u

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ08

    40. NM_001406224.1 → NP_001393153.1  GA-binding protein subunit beta-1 isoform y

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ08

    41. NM_001406225.1 → NP_001393154.1  GA-binding protein subunit beta-1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AL844555
      UniProtKB/TrEMBL
      Q6WJ08

    42. NM_001406226.1 → NP_001393155.1  GA-binding protein subunit beta-1 isoform w

      Status: VALIDATED

      Source sequence(s)
      AL844555

    43. NM_001406227.1 → NP_001393156.1  GA-binding protein subunit beta-1 isoform w

      Status: VALIDATED

      Source sequence(s)
      AL844555

    44. NM_010249.3 → NP_034379.1  GA-binding protein subunit beta-1 isoform b

      See identical proteins and their annotated locations for NP_034379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) (also known as Gabp-beta-2, GABBP2, Gabp-beta-1-2, GABPbeta1S) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS16686.1
      UniProtKB/TrEMBL
      Q3UJN3
      Related
      ENSMUSP00000099516.4, ENSMUST00000103226.10
      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    45. NM_207669.3 → NP_997552.1  GA-binding protein subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_997552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) (also known as Gabp-beta-1, GABBP1, Gabp-beta-1-1, GABPbeta1L) encodes isoform a.
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS16685.1
      UniProtKB/TrEMBL
      Q3UJN3, Q3US22
      Related
      ENSMUSP00000106054.3, ENSMUST00000110424.9
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315 → 369
      Oberon_cc; Coiled-coil region of Oberon

    RNA

    1. NR_073183.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two internal exons and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL844555

    2. NR_176024.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    3. NR_176025.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    4. NR_176026.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    5. NR_176027.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    6. NR_176028.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    7. NR_176029.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    8. NR_176030.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    9. NR_176031.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    10. NR_176032.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844555

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126470832..126527184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158371.1 → XP_036014264.1  GA-binding protein subunit beta-1 isoform X15

      UniProtKB/TrEMBL
      Q6WJ09
      Conserved Domains (3) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036158350.1 → XP_036014243.1  GA-binding protein subunit beta-1 isoform X6

      UniProtKB/TrEMBL
      Q3UJN3
      Conserved Domains (3) summary
      sd00045
      Location:46 → 76
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:18 → 66
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:50 → 141
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_030247528.1 → XP_030103388.1  GA-binding protein subunit beta-1 isoform X13

      UniProtKB/TrEMBL
      Q6WJ09
      Conserved Domains (3) summary
      sd00045
      Location:46 → 76
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50 → 141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:18 → 66
      Ank_4; Ankyrin repeats (many copies)

    4. XM_036158372.1 → XP_036014265.1  GA-binding protein subunit beta-1 isoform X16

      Conserved Domains (2) summary
      sd00045
      Location:10 → 35
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10 → 92
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006498761.5 → XP_006498824.1  GA-binding protein subunit beta-1 isoform X4

      See identical proteins and their annotated locations for XP_006498824.1

      UniProtKB/TrEMBL
      Q3UJN3, Q3US22
      Conserved Domains (4) summary
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315 → 369
      Oberon_cc; Coiled-coil region of Oberon

    6. XM_006498756.2 → XP_006498819.1  GA-binding protein subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3UJN3
      Conserved Domains (4) summary
      sd00045
      Location:46 → 76
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50 → 141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:18 → 66
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:323 → 377
      Oberon_cc; Coiled-coil region of Oberon

    7. XM_036158356.1 → XP_036014249.1  GA-binding protein subunit beta-1 isoform X10

      UniProtKB/TrEMBL
      Q3UJN3
      Conserved Domains (3) summary
      sd00045
      Location:10 → 35
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10 → 92
      Ank_2; Ankyrin repeats (3 copies)
      pfam16312
      Location:250 → 304
      Oberon_cc; Coiled-coil region of Oberon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00420.2 GenPept UniProtKB/Swiss-Prot:Q00420

    Gene LinkOut

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