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    Atp13a3 ATPase type 13A3 [ Mus musculus (house mouse) ]

    Gene ID: 224088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp13a3provided by MGI
    Official Full Name
    ATPase type 13A3provided by MGI
    Primary source
    MGI:MGI:2685387
    See related
    Ensembl:ENSMUSG00000022533 AllianceGenome:MGI:2685387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm541; Gm542; Gm1745
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type transmembrane transporter activity; and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in late endosome membrane. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 11.5), placenta adult (RPKM 10.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp13a3 in Genome Data Viewer
    Location:
    16 B2; 16 21.26 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30131241..30207674, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30312423..30388871, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein 5 platelet Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene transmembrane protein 44 Neighboring gene STARR-seq mESC enhancer starr_40580 Neighboring gene predicted gene, 52252 Neighboring gene STARR-seq mESC enhancer starr_40581 Neighboring gene STARR-seq mESC enhancer starr_40582 Neighboring gene predicted gene, 53946 Neighboring gene large 60S subunit nuclear export GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport. Liu B, et al. Cardiovasc Res, 2024 May 29. PMID 38626311, Free PMC Article
    2. Characterization of the P5 subfamily of P-type transport ATPases in mice. Schultheis PJ, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381061
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.
      Title: ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type putrescine transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables P-type transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    polyamine-transporting ATPase 13A3
    Names
    probable cation-transporting ATPase 13A3
    putrescine transporting ATPase
    type V P-type ATPase
    NP_001121566.1
    NP_001121568.1
    XP_011244181.1
    XP_036015785.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128094.1 → NP_001121566.1  polyamine-transporting ATPase 13A3 isoform 2

      See identical proteins and their annotated locations for NP_001121566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC154608, BK005558
      Consensus CDS
      CCDS49820.1
      UniProtKB/Swiss-Prot
      Q5XF89
      Related
      ENSMUSP00000051645.7, ENSMUST00000061350.13
      Conserved Domains (6) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:232 → 479
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:174 → 222
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12409
      Location:13 → 141
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:618 → 658
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:817 → 894
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001128096.1 → NP_001121568.1  polyamine-transporting ATPase 13A3 isoform 1

      See identical proteins and their annotated locations for NP_001121568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154608
      Consensus CDS
      CCDS49821.1
      UniProtKB/Swiss-Prot
      Q5XF89
      Related
      ENSMUSP00000128224.2, ENSMUST00000100013.9
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30131241..30207674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245879.4 → XP_011244181.1  polyamine-transporting ATPase 13A3 isoform X2

      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1115
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    2. XM_036159892.1 → XP_036015785.1  polyamine-transporting ATPase 13A3 isoform X1

      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    RNA

    1. XR_004939186.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XF89.1 GenPept UniProtKB/Swiss-Prot:Q5XF89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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