Tlk1 tousled-like kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlk1provided by MGI
Official Full Name: tousled-like kinase 1provided by MGI
Primary source: MGI:MGI:2441683
See related: Ensembl:ENSMUSG00000041997 AllianceGenome:MGI:2441683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930545J15Rik
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 41.9 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (70542751..70656505, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (70712407..70825816, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircTLK1: A novel regulator involved in VSMC phenotypic switching and the developmental process of atherosclerosis.
Title: CircTLK1: A novel regulator involved in VSMC phenotypic switching and the developmental process of atherosclerosis.
Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
Title: Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
Title: CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
Title: The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.
Title: Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells.
TLK1 and TLK2 have largely redundant roles in genome maintenance.
Title: Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.
Title: TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa59g9.seq (e-PCR)
- UniSTS:125240

D2Mit56 (e-PCR), detects polymorphism
- UniSTS:129451

NoName (e-PCR)
- UniSTS:234425

NoName (e-PCR)
- UniSTS:234426

Tlk1 (e-PCR), detects polymorphism
- UniSTS:527581

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase tousled-like 1

NP_001349892.1

EC 2.7.11.1

NP_766252.2

EC 2.7.11.1

XP_006499251.1

EC 2.7.11.1

XP_006499252.1

EC 2.7.11.1

XP_006499254.1

EC 2.7.11.1

XP_006499256.1

EC 2.7.11.1

XP_017173069.1

EC 2.7.11.1

XP_017173070.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362963.1 → NP_001349892.1 serine/threonine-protein kinase tousled-like 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL928868, BX000490

Conserved Domains (1) summary

cd14040
Location:401 → 699

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
NM_172664.3 → NP_766252.2 serine/threonine-protein kinase tousled-like 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC051641

Consensus CDS

CCDS50599.1

UniProtKB/Swiss-Prot

Q8C0V0

Related

ENSMUSP00000035961.9, ENSMUST00000038584.9

Conserved Domains (2) summary

smart00220
Location:467 → 734

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14040
Location:449 → 747

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

NR_156420.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL928868, BC057369, BX000490

Related

ENSMUST00000135128.8
NR_156421.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK045308, BX000490

Related

ENSMUST00000124629.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

70542751..70656505 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499193.2 → XP_006499256.1 serine/threonine-protein kinase tousled-like 1 isoform X3

UniProtKB/TrEMBL

Q6A0C1

Conserved Domains (1) summary

cd14040
Location:232 → 530

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
XM_006499189.4 → XP_006499252.1 serine/threonine-protein kinase tousled-like 1 isoform X2

Conserved Domains (1) summary

cl21453
Location:449 → 711

PKc_like; Protein Kinases, catalytic domain
XM_006499191.3 → XP_006499254.1 serine/threonine-protein kinase tousled-like 1 isoform X3

UniProtKB/TrEMBL

Q6A0C1

Conserved Domains (1) summary

cd14040
Location:232 → 530

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
XM_006499188.5 → XP_006499251.1 serine/threonine-protein kinase tousled-like 1 isoform X1

Conserved Domains (1) summary

cd14040
Location:417 → 715

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
XM_017317581.1 → XP_017173070.1 serine/threonine-protein kinase tousled-like 1 isoform X3

UniProtKB/TrEMBL

Q6A0C1

Conserved Domains (1) summary

cd14040
Location:232 → 530

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
XM_017317580.3 → XP_017173069.1 serine/threonine-protein kinase tousled-like 1 isoform X3

UniProtKB/TrEMBL

Q6A0C1

Conserved Domains (1) summary

cd14040
Location:232 → 530

STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1