Isoc2a isochorismatase domain containing 2a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isoc2aprovided by MGI
Official Full Name: isochorismatase domain containing 2aprovided by MGI
Primary source: MGI:MGI:3609243
See related: Ensembl:ENSMUSG00000086784 AllianceGenome:MGI:3609243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Isoc2
Summary: Predicted to be involved in protein destabilization. Located in mitochondrion. Orthologous to human ISOC2 (isochorismatase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 208.4), liver adult (RPKM 113.8) and 21 other tissues See more
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Genomic context

Location:: 7 A1; 7 2.82 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4880052..4898716)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4877053..4895717)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isochorismatase domain-containing protein 2A

Names: isochorismatase domain-containing protein 2A, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101598.1 → NP_001095068.1 isochorismatase domain-containing protein 2A precursor

See identical proteins and their annotated locations for NP_001095068.1

Status: VALIDATED

Source sequence(s)

AC157563, BC158139, BG404719

Consensus CDS

CCDS51978.1

UniProtKB/Swiss-Prot

P85094

UniProtKB/TrEMBL

B2RY90

Related

ENSMUSP00000131514.2, ENSMUST00000125249.3

Conserved Domains (1) summary

cd01012
Location:18 → 170

YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...