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    Sec16a SEC16 homolog A, endoplasmic reticulum export factor [ Mus musculus (house mouse) ]

    Gene ID: 227648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec16aprovided by MGI
    Official Full Name
    SEC16 homolog A, endoplasmic reticulum export factorprovided by MGI
    Primary source
    MGI:MGI:2139207
    See related
    Ensembl:ENSMUSG00000026924 AllianceGenome:MGI:2139207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p250; C230052J16Rik
    Summary
    Involved in endoplasmic reticulum organization; protein exit from endoplasmic reticulum; and protein localization to plasma membrane. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Is expressed in cerebral cortex. Orthologous to human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 22.5), ovary adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec16a in Genome Data Viewer
    Location:
    2 A3; 2 18.89 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26299443..26336138, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26409431..26446293, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endosome associated trafficking regulator 1 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene STARR-positive B cell enhancer ABC_E5900 Neighboring gene RIKEN cDNA 0610009E02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1241 Neighboring gene STARR-seq mESC enhancer starr_03982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26316530-26316713 Neighboring gene notch 1 Neighboring gene microRNA 6996 Neighboring gene STARR-positive B cell enhancer ABC_E2031 Neighboring gene predicted gene, 35978

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress. Wang MJ, et al. Adv Sci (Weinh), 2024 Oct. PMID 39119875, Free PMC Article
    2. Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. Iinuma T, et al. J Biol Chem, 2007 Jun 15. PMID 17428803
    3. Nbeal2 interacts with Dock7, Sec16a, and Vac14. Mayer L, et al. Blood, 2018 Mar 1. PMID 29187380, Free PMC Article
    4. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. Bruno J, et al. J Cell Biol, 2016 Jul 4. PMID 27354378, Free PMC Article
    5. Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. Cho HJ, et al. EMBO J, 2014 Oct 16. PMID 25201882, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
      Title: SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
    2. SEC16A and RAB10 promote insulin-stimulated mobilization of GLUT4 from a perinuclear recycling endosome/trans Golgi network compartment.
      Title: SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38812

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein transport protein Sec16A
    NP_694765.2
    XP_006497973.2
    XP_006497974.1
    XP_006497976.1
    XP_011237375.1
    XP_030105628.2
    XP_036016658.1
    XP_036016660.1
    XP_036016666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153125.2 → NP_694765.2  protein transport protein Sec16A

      Status: VALIDATED

      Source sequence(s)
      AA388295, AI851539, AK122242, AK162931, BC034649, BF456838, BQ950511, BU704044, CA463107, CJ098463, CK638146, CO432077, CV883992, CX236472
      Consensus CDS
      CCDS38085.1
      UniProtKB/Swiss-Prot
      A2AIX1, E9QAT4, Q80U43, Q811L5
      Related
      ENSMUSP00000088796.5, ENSMUST00000091252.5
      Conserved Domains (4) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      pfam10697
      Location:1270 → 1332
      DUF2502; Protein of unknown function (DUF2502)
      cl25764
      Location:58 → 285
      PAT1; Topoisomerase II-associated protein PAT1
      cl26464
      Location:669 → 1241
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26299443..26336138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497910.5 → XP_006497973.2  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2 → 291
      PHA03247; large tegument protein UL36; Provisional

    2. XM_030249768.2 → XP_030105628.2  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2 → 291
      PHA03247; large tegument protein UL36; Provisional

    3. XM_011239073.3 → XP_011237375.1  protein transport protein Sec16A isoform X6

      Conserved Domains (4) summary
      cd09233
      Location:1280 → 1642
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:667 → 1009
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58 → 285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:1038 → 1100
      DUF2502; Protein of unknown function (DUF2502)

    4. XM_036160773.1 → XP_036016666.1  protein transport protein Sec16A isoform X5

      Conserved Domains (2) summary
      cd09233
      Location:1280 → 1642
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2 → 291
      PHA03247; large tegument protein UL36; Provisional

    5. XM_006497913.4 → XP_006497976.1  protein transport protein Sec16A isoform X4

      Conserved Domains (4) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:669 → 1241
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58 → 285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:1270 → 1332
      DUF2502; Protein of unknown function (DUF2502)

    6. XM_036160767.1 → XP_036016660.1  protein transport protein Sec16A isoform X2

      Conserved Domains (2) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2 → 291
      PHA03247; large tegument protein UL36; Provisional

    7. XM_006497911.4 → XP_006497974.1  protein transport protein Sec16A isoform X3

      UniProtKB/TrEMBL
      A2AIX1
      Related
      ENSMUSP00000109716.3, ENSMUST00000114082.9
      Conserved Domains (4) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:669 → 1241
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58 → 285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:1270 → 1332
      DUF2502; Protein of unknown function (DUF2502)

    8. XM_036160765.1 → XP_036016658.1  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:1512 → 1874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2 → 291
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9QAT4.1 GenPept UniProtKB/Swiss-Prot:E9QAT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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