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    Dars1 aspartyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 226414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dars1provided by MGI
    Official Full Name
    aspartyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:2442544
    See related
    Ensembl:ENSMUSG00000026356 AllianceGenome:MGI:2442544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dars; 5730439G15Rik
    Summary
    Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Located in cytoplasm and synapse. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 27.3), placenta adult (RPKM 26.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dars1 in Genome Data Viewer
    Location:
    1 E3; 1 55.8 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128291444..128345153, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128363707..128417416, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lactase Neighboring gene minichromosome maintenance complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E7743 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130255918-130256027 Neighboring gene STARR-positive B cell enhancer ABC_E2006 Neighboring gene STARR-positive B cell enhancer ABC_E8774 Neighboring gene STARR-positive B cell enhancer mm9_chr1:130268768-130269068 Neighboring gene STARR-seq mESC enhancer starr_02162 Neighboring gene STARR-seq mESC enhancer starr_02163 Neighboring gene STARR-positive B cell enhancer ABC_E1229 Neighboring gene STARR-seq mESC enhancer starr_02170 Neighboring gene predicted gene, 23902 Neighboring gene predicted gene, 25384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Fröhlich D, et al. Neurobiol Dis, 2017 Jan. PMID 27816769
    2. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article
    3. Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Guo Y, et al. Signal Transduct Target Ther, 2024 Feb 14. PMID 38351062, Free PMC Article
    4. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
    5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartate--tRNA ligase, cytoplasmic
    Names
    aspRS
    aspartyl-tRNA synthetase, cytoplasmic
    NP_663482.2
    NP_803228.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145507.2 → NP_663482.2  aspartate--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_663482.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate 3' exon, but it lacks several exons in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK077820, BB576692, BY308833
      Consensus CDS
      CCDS48348.1
      UniProtKB/TrEMBL
      Q8BJY7
      Related
      ENSMUSP00000066866.8, ENSMUST00000064309.9
      Conserved Domains (1) summary
      cl09930
      Location:60 → 72
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    2. NM_177445.5 → NP_803228.2  aspartate--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_803228.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK151027, BY276340, CO043663
      Consensus CDS
      CCDS15253.1
      UniProtKB/Swiss-Prot
      Q3U987, Q922B2
      UniProtKB/TrEMBL
      Q3TF87, Q3TMC5, Q8BK18
      Related
      ENSMUSP00000027602.9, ENSMUST00000027602.15
      Conserved Domains (3) summary
      PLN02850
      Location:20 → 501
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:174 → 497
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:60 → 158
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      128291444..128345153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922B2.2 GenPept UniProtKB/Swiss-Prot:Q922B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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