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    Mdfic2 MyoD family inhibitor domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 330390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdfic2provided by MGI
    Official Full Name
    MyoD family inhibitor domain containing 2provided by MGI
    Primary source
    MGI:MGI:2685611
    See related
    Ensembl:ENSMUSG00000090667 AllianceGenome:MGI:2685611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm765
    Summary
    Predicted to be involved in negative regulation of DNA-templated transcription; regulation of JNK cascade; and regulation of Wnt signaling pathway. Predicted to be active in nucleus. Orthologous to human MDFIC2 (MyoD family inhibitor domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mdfic2 in Genome Data Viewer
    Location:
    6 D3; 6 45.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (98212665..98319715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (98238014..98342754, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene melanogenesis associated transcription factor Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16804 Neighboring gene STARR-seq mESC enhancer starr_16808 Neighboring gene predicted gene, 53321 Neighboring gene STARR-seq mESC enhancer starr_16809 Neighboring gene predicted gene, 53320 Neighboring gene VISTA enhancer mm60 Neighboring gene predicted gene, 32592 Neighboring gene predicted gene, 32535 Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_16810 Neighboring gene STARR-seq mESC enhancer starr_16811 Neighboring gene predicted gene, 32646 Neighboring gene STARR-seq mESC enhancer starr_16812 Neighboring gene predicted gene, 32705

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myoD family inhibitor domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128092.1 → NP_001121564.1  myoD family inhibitor domain-containing protein 2

      See identical proteins and their annotated locations for NP_001121564.1

      Status: PROVISIONAL

      Source sequence(s)
      BC147266
      Consensus CDS
      CCDS51863.1
      UniProtKB/TrEMBL
      B2RVL9
      Related
      ENSMUSP00000127120.2, ENSMUST00000164491.3
      Conserved Domains (1) summary
      pfam15316
      Location:25 → 189
      MDFI; MyoD family inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      98212665..98319715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166250.1 → XP_036022143.1  myoD family inhibitor domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15316
      Location:52 → 211
      MDFI; MyoD family inhibitor
    Nucleotide Protein
    Heading Accession and Version

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