U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gsg1l GSG1-like [ Mus musculus (house mouse) ]

    Gene ID: 269994, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gsg1lprovided by MGI
    Official Full Name
    GSG1-likeprovided by MGI
    Primary source
    MGI:MGI:2685483
    See related
    Ensembl:ENSMUSG00000046182 AllianceGenome:MGI:2685483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    g1l; Gm637; C230098I05Rik; G630023A01Rik
    Summary
    Involved in regulation of postsynaptic neurotransmitter receptor internalization. Located in asymmetric synapse. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in brain; chondrocranium; and neural tube. Orthologous to human GSG1L (GSG1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 69.5), cortex adult (RPKM 12.4) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gsg1l in Genome Data Viewer
    Location:
    7 F3; 7 69.01 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125477584..125681929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125878412..126082757, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene general transcription factor III C 1 Neighboring gene STARR-positive B cell enhancer ABC_E2848 Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174 Neighboring gene STARR-seq mESC enhancer starr_20126 Neighboring gene predicted gene, 51456 Neighboring gene STARR-seq mESC enhancer starr_20127 Neighboring gene exportin 6 Neighboring gene STARR-seq mESC enhancer starr_20131 Neighboring gene LAG1 homolog, ceramide synthase 2 pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. Kamalova A, et al. Cell Rep, 2020 Jul 21. PMID 32697982, Free PMC Article
    2. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Gu X, et al. Nat Commun, 2016 Mar 2. PMID 26932439, Free PMC Article
    3. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
    4. TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Caubit X, et al. Nat Genet, 2016 Nov. PMID 27668656, Free PMC Article
    5. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
      Title: AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    germ cell-specific gene 1-like protein
    Names
    GSG1-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101488.2 → NP_001094958.1  germ cell-specific gene 1-like protein isoform 1

      See identical proteins and their annotated locations for NP_001094958.1

      Status: VALIDATED

      Source sequence(s)
      AC012297, AC150648
      Consensus CDS
      CCDS52395.1
      UniProtKB/Swiss-Prot
      D3Z7H4
      Related
      ENSMUSP00000073591.6, ENSMUST00000073935.7
      Conserved Domains (2) summary
      pfam07803
      Location:24 → 122
      GSG-1; GSG1-like protein
      cl21598
      Location:92 → 225
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001358885.2 → NP_001345814.1  germ cell-specific gene 1-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012297, AC150648
      Conserved Domains (1) summary
      pfam07803
      Location:24 → 122
      GSG-1; GSG1-like protein

    3. NM_001419659.1 → NP_001406588.1  germ cell-specific gene 1-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC012297, AC150648

    4. NM_001419660.1 → NP_001406589.1  germ cell-specific gene 1-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC012297, AC150648

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125477584..125681929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242625.1 → XP_030098485.1  germ cell-specific gene 1-like protein isoform X1

    2. XM_030242626.1 → XP_030098486.1  germ cell-specific gene 1-like protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z7H4.2 GenPept UniProtKB/Swiss-Prot:D3Z7H4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools