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    Neurl3 neuralized E3 ubiquitin protein ligase 3 [ Mus musculus (house mouse) ]

    Gene ID: 214854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neurl3provided by MGI
    Official Full Name
    neuralized E3 ubiquitin protein ligase 3provided by MGI
    Primary source
    MGI:MGI:2429944
    See related
    Ensembl:ENSMUSG00000047180 AllianceGenome:MGI:2429944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lincr; 2010300P06Rik
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in early endosome. Is expressed in central nervous system; dorsal root ganglion; lung epithelium; metanephros; and renal vasculature. Orthologous to human NEURL3 (neuralized E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 50.5), small intestine adult (RPKM 43.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neurl3 in Genome Data Viewer
    Location:
    1 B; 1 15.18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36303683..36313755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36264602..36274674, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1 Neighboring gene elongation factor RNA polymerase II 2 pseudogene Neighboring gene predicted gene, 39625 Neighboring gene STARR-positive B cell enhancer ABC_E4308 Neighboring gene STARR-positive B cell enhancer ABC_E3268 Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene microRNA 6898

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes. Londhe VA, et al. Dev Dyn, 2015 Jul. PMID 25904058
    2. Glucocorticoid-attenuated response genes induced in the lung during endotoxemia. Smith JB, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Sep. PMID 12169584
    3. Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development. Ning X, et al. J Genet Genomics, 2023 Sep. PMID 37230320
    4. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Hou S, et al. Cell Res, 2020 May. PMID 32203131, Free PMC Article
    5. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. Hu Y, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936721

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
      Title: Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
    2. E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
      Title: E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
    3. LINCR may exert its effects on distal lung development in this model through activation of the Notch signaling pathway.
      Title: Overexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEURL3
    Names
    E3 ubiquitin-protein ligase LINCR
    RING-type E3 ubiquitin transferase NEURL3
    lung inducible neuralized-related C3HC4 RING finger
    lung-inducible neuralized-related C3CH4 RING domain protein
    lung-inducible neuralized-related C3CH4 RING domain-containing protein
    lung-inducible neuralized-related C3HC4 RING domain protein
    neuralized homolog 3 homolog
    neuralized-like protein 3
    NP_700457.1
    XP_006495909.1
    XP_006495910.1
    XP_006495911.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153408.2 → NP_700457.1  E3 ubiquitin-protein ligase NEURL3

      See identical proteins and their annotated locations for NP_700457.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132456, AC133102
      Consensus CDS
      CCDS14875.1
      UniProtKB/Swiss-Prot
      Q8BS05, Q8CJC5
      Related
      ENSMUSP00000055437.7, ENSMUST00000056946.8
      Conserved Domains (2) summary
      cd16552
      Location:195 → 236
      RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
      pfam07177
      Location:20 → 173
      Neuralized

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36303683..36313755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495848.4 → XP_006495911.1  E3 ubiquitin-protein ligase NEURL3 isoform X2

      See identical proteins and their annotated locations for XP_006495911.1

      UniProtKB/Swiss-Prot
      Q8BS05, Q8CJC5
      Conserved Domains (2) summary
      cd16552
      Location:195 → 236
      RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
      pfam07177
      Location:20 → 173
      Neuralized

    2. XM_006495847.1 → XP_006495910.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

      See identical proteins and their annotated locations for XP_006495910.1

      Conserved Domains (2) summary
      cd16552
      Location:209 → 250
      RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
      pfam07177
      Location:34 → 187
      Neuralized

    3. XM_006495846.4 → XP_006495909.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

      See identical proteins and their annotated locations for XP_006495909.1

      Conserved Domains (2) summary
      cd16552
      Location:209 → 250
      RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins
      pfam07177
      Location:34 → 187
      Neuralized
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJC5.1 GenPept UniProtKB/Swiss-Prot:Q8CJC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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