Mrap2 melanocortin 2 receptor accessory protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrap2provided by MGI
Official Full Name: melanocortin 2 receptor accessory protein 2provided by MGI
Primary source: MGI:MGI:3609239
See related: Ensembl:ENSMUSG00000042761 AllianceGenome:MGI:3609239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables signaling receptor regulator activity and type 4 melanocortin receptor binding activity. Involved in energy homeostasis; energy reserve metabolic process; and feeding behavior. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 1.9), frontal lobe adult (RPKM 0.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 46.76 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (87026293..87066104)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (87144236..87184051)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arginine 125 Is an Essential Residue for the Function of MRAP2.
Title: Arginine 125 Is an Essential Residue for the Function of MRAP2.
Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.
Title: Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.
MRAP2 in paraventricular MC4R neurons controls energy intake and expenditure.
Title: Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure.
MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus.
Title: MRAP2 regulates ghrelin receptor signaling and hunger sensing.
Mrap2 KO mice have a significant increase in body weight, with increased fat and lean mass, but without detectable changes in food intake or energy expenditure. Transcriptomic analysis showed significantly decreased expression of Sim1, Trh, Oxt and Crh within the paraventricular nucleus of Mrap2 KO mice. Circulating levels of both high-density and low-density lipoprotein were increased in Mrap2 KO mice.
Title: Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.
show that MRAP2 significantly and specifically inhibits PKR1 signaling.
Title: The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity.
Title: Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production.
Title: The C-terminal domains of melanocortin-2 receptor (MC2R) accessory proteins (MRAP1) influence their localization and ACTH-induced cAMP production.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

General gene information

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Markers

RH126855 (e-PCR)
- UniSTS:209751

D9Mit9.2 (e-PCR), detects polymorphism
- UniSTS:131977

NoName (e-PCR)
- UniSTS:236212

D9Mit271 (e-PCR), detects polymorphism
- UniSTS:142797

D9Mit271 (e-PCR), detects polymorphism
- UniSTS:131838

D9Mit271.1 (e-PCR), detects polymorphism
- UniSTS:131839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables corticotropin hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables corticotropin hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables type 1 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 3 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 3 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 3 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 4 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 4 melanocortin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 4 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 5 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 5 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 5 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy reserve metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanocortin-2 receptor accessory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101482.2 → NP_001094952.2 melanocortin-2 receptor accessory protein 2

See identical proteins and their annotated locations for NP_001094952.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.

Source sequence(s)

AC125370, AC168882, BQ175739

Consensus CDS

CCDS52878.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Related

ENSMUSP00000046271.8, ENSMUST00000049457.14

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
NM_001177731.1 → NP_001171202.1 melanocortin-2 receptor accessory protein 2

See identical proteins and their annotated locations for NP_001171202.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 through 3 encode the same protein.

Source sequence(s)

AC125370, AC168882, BQ175739, CJ059941

Consensus CDS

CCDS52878.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Related

ENSMUSP00000135904.2, ENSMUST00000179313.3

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
NM_001359955.1 → NP_001346884.1 melanocortin-2 receptor accessory protein 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.

Source sequence(s)

AC125370, AC168882, BQ175739

Consensus CDS

CCDS52878.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
NM_001421369.1 → NP_001408298.1 melanocortin-2 receptor accessory protein 2

Status: VALIDATED

Source sequence(s)

AC125370, AC168882

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746
NM_001421370.1 → NP_001408299.1 melanocortin-2 receptor accessory protein 2

Status: VALIDATED

Source sequence(s)

AC125370, AC168882

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746
NM_001421371.1 → NP_001408300.1 melanocortin-2 receptor accessory protein 2

Status: VALIDATED

Source sequence(s)

AC125370, AC168882

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

87026293..87066104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511176.4 → XP_006511239.1 melanocortin-2 receptor accessory protein 2 isoform X1

See identical proteins and their annotated locations for XP_006511239.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
XM_006511179.4 → XP_006511242.1 melanocortin-2 receptor accessory protein 2 isoform X1

See identical proteins and their annotated locations for XP_006511242.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Related

ENSMUSP00000108774.2, ENSMUST00000113149.8

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
XM_030244385.2 → XP_030100245.1 melanocortin-2 receptor accessory protein 2 isoform X1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
XM_006511177.5 → XP_006511240.1 melanocortin-2 receptor accessory protein 2 isoform X1

See identical proteins and their annotated locations for XP_006511240.1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family
XM_036155010.1 → XP_036010903.1 melanocortin-2 receptor accessory protein 2 isoform X1

UniProtKB/Swiss-Prot

D3YVA7, D3YZ75, D3Z1Q2, D3Z746

Conserved Domains (1) summary

pfam15183
Location:16 → 101

MRAP; Melanocortin-2 receptor accessory protein family