Upk3a uroplakin 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Upk3aprovided by MGI
Official Full Name: uroplakin 3Aprovided by MGI
Primary source: MGI:MGI:98914
See related: Ensembl:ENSMUSG00000022435 AllianceGenome:MGI:98914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UP3a; Upk3; UPIII; 1110017C07Rik
Summary: Acts upstream of or within several processes, including potassium ion homeostasis; urea transport; and urinary bladder development. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in several structures, including alimentary system; genitourinary system; lung; notochord; and olfactory epithelium. Used to study vesicoureteral reflux. Orthologous to human UPK3A (uroplakin 3A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward bladder adult (RPKM 458.1) See more
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 40.25 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (84901342..84906761)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (85017141..85022560)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

U-CCs (Uroplakin3a expressing cells )proliferate and generate CCs and ciliated cells in uninjured airways long-term and, like v-CCs, after Nap. U-CCs have a higher propensity to generate ciliated cells than non-U-CCs
Title: Uroplakin 3a(+) Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.
A UPK3A peptide can induce a peptide-specific CD4+ T cell autoimmunity that mediates painful bladder dysfunction in mice.
Title: Uroplakin peptide-specific autoimmunity initiates interstitial cystitis/painful bladder syndrome in mice.
role of uroplakins in CO2 transport through urothelium
Title: Uroplakins do not restrict CO2 transport through urothelium.
The despites a lower level of expression, UPIIIa maintain its plaque association in urothelial preneoplastic lesions.
Title: Expression and localization of four uroplakins in urothelial preneoplastic lesions.
structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography
Title: Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492912

Upk3a (e-PCR), detects polymorphism
- UniSTS:496534

Upk3a (e-PCR), detects polymorphism
- UniSTS:527019

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urea transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within urea transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within urinary bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within water transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane urothelial plaque	EXP Inferred from Experiment more info	PubMed
is_active_in apical plasma membrane urothelial plaque	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uroplakin-3a

Names: proplakin IIIa; uroplakin 3; uroplakin III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.