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    Dazap2 DAZ associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dazap2provided by RGD
    Official Full Name
    DAZ associated protein 2provided by RGD
    Primary source
    RGD:1307407
    See related
    EnsemblRapid:ENSRNOG00000004628 AllianceGenome:RGD:1307407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and p53 binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Orthologous to human DAZAP2 (DAZ associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1223.0), Heart (RPKM 1012.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dazap2 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133593503..133599044)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131714749..131720266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142238780..142244301)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479579 Neighboring gene uncharacterized LOC134479580 Neighboring gene small cell adhesion glycoprotein Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene chymotrypsin like elastase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. Hamilton MH, et al. J Biol Chem, 2001 Jul 13. PMID 11342538
    2. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Winkel A, et al. Cell Signal, 2008 Nov. PMID 18762249
    3. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Tsui S, et al. Genomics, 2000 May 1. PMID 10857750
    4. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DAZ-associated protein 2
    Names
    deleted in azoospermia-associated protein 2
    proline-rich transcript in brain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395672.1 → NP_001382601.1  DAZ-associated protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      A0A0H2UHD1, P60486
      Conserved Domains (1) summary
      pfam11029
      Location:35 → 168
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    2. NM_001395673.1 → NP_001382602.1  DAZ-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Conserved Domains (1) summary
      pfam11029
      Location:1 → 108
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133593503..133599044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078934.2 → XP_038934862.1  DAZ-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A0A0H2UHD1, P60486
      Related
      ENSRNOP00000006239.6, ENSRNOT00000006239.9
      Conserved Domains (1) summary
      pfam11029
      Location:35 → 168
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013107.1: Suppressed sequence

      Description
      NM_001013107.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60486.2 GenPept UniProtKB/Swiss-Prot:P60486

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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