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    PPT2 holo-[acyl-carrier-protein] synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PPT2
    Official Full Name
    holo-[acyl-carrier-protein] synthase
    Primary source
    SGD:S000006069
    Locus tag
    YPL148C
    See related
    AllianceGenome:SGD:S000006069; FungiDB:YPL148C; VEuPathDB:YPL148C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables holo-[acyl-carrier-protein] synthase activity. Involved in holo-[acyl-carrier-protein] biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PPT2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (272294..272815, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Atg5p Neighboring gene ATP-binding cassette long-chain fatty acid transporter PXA1 Neighboring gene Nop53p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. Stuible HP, et al. J Biol Chem, 1998 Aug 28. PMID 9712852
    2. The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis. Van Vranken JG, et al. Elife, 2016 Aug 19. PMID 27540631, Free PMC Article
    3. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Qin T, et al. Nucleic Acids Res, 2014 Oct. PMID 25063300, Free PMC Article
    4. Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae. Mora-García M, et al. Curr Genet, 2022 Aug. PMID 35660944
    5. Mitochondrial ER contacts are crucial for mitophagy in yeast. Böckler S, et al. Dev Cell, 2014 Feb 24. PMID 24530295

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables holo-[acyl-carrier-protein] synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables holo-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in holo-[acyl-carrier-protein] biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    holo-[acyl-carrier-protein] synthase
    NP_015177.2
    • Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      272294..272815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183962.1 → NP_015177.2  TPA: holo-[acyl-carrier-protein] synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015177.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3M1, Q12036
      UniProtKB/TrEMBL
      A6ZWA6, B3LKT0, C7GJ99, G2WP35
      Conserved Domains (1) summary
      COG0736
      Location:12 → 173
      AcpS; Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12036.2

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