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    INTS15 integrator complex subunit 15 [ Homo sapiens (human) ]

    Gene ID: 79034, updated on 27-Dec-2024

    Summary

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    Official Symbol
    INTS15provided by HGNC
    Official Full Name
    integrator complex subunit 15provided by HGNC
    Primary source
    HGNC:HGNC:21702
    See related
    Ensembl:ENSG00000146576 AllianceGenome:HGNC:21702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C7orf26
    Summary
    Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 9.0), spleen (RPKM 8.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INTS15 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6590021..6608726)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6709194..6727910)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6629652..6648357)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25629 Neighboring gene Grid2 interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6576361-6577340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6617713-6618328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene uncharacterized LOC124901582 Neighboring gene zinc finger DHHC-type palmitoyltransferase 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene zinc finger protein 853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25632 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies. Drew K, et al. Mol Syst Biol, 2021 May. PMID 33973408, Free PMC Article
    2. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Azuma N, et al. Hum Mol Genet, 2023 Jun 5. PMID 36851842
    3. Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function. Lin MH, et al. Mol Cell, 2024 Aug 8. PMID 39032490,
    4. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. Navare AT, et al. J Cell Biol, 2022 Nov 7. PMID 36305789, Free PMC Article
    5. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development.
      Title: Integrator complex subunit 15 controls mRNA splicing and is critical for eye development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2718

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator complex subunit 15
    Names
    uncharacterized protein C7orf26

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303039.2 → NP_001289968.1  integrator complex subunit 15 isoform 2

      See identical proteins and their annotated locations for NP_001289968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame segment in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC001076, BI599533, BM977018, CA454040
      Consensus CDS
      CCDS78206.1
      UniProtKB/Swiss-Prot
      Q96N11
      Related
      ENSP00000351974.5, ENST00000359073.9
      Conserved Domains (1) summary
      pfam14964
      Location:2 → 284
      DUF4507; Domain of unknown function (DUF4507)

    2. NM_024067.4 → NP_076972.2  integrator complex subunit 15 isoform 1

      See identical proteins and their annotated locations for NP_076972.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK056149, BI599533, BM977018, CA454040
      Consensus CDS
      CCDS5353.1
      UniProtKB/Swiss-Prot
      Q96N11, Q9BQ43
      Related
      ENSP00000340220.5, ENST00000344417.10
      Conserved Domains (1) summary
      pfam14964
      Location:2 → 381
      DUF4507; Domain of unknown function (DUF4507)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      6590021..6608726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515518.4 → XP_011513820.2  integrator complex subunit 15 isoform X2

    2. XM_005249845.6 → XP_005249902.1  integrator complex subunit 15 isoform X1

      Conserved Domains (1) summary
      pfam14964
      Location:2 → 381
      DUF4507; Domain of unknown function (DUF4507)

    3. XM_047420833.1 → XP_047276789.1  integrator complex subunit 15 isoform X4

    4. XM_017012614.3 → XP_016868103.1  integrator complex subunit 15 isoform X3

    RNA

    1. XR_926946.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6709194..6727910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358996.1 → XP_054214971.1  integrator complex subunit 15 isoform X2

    2. XM_054358995.1 → XP_054214970.1  integrator complex subunit 15 isoform X1

    3. XM_054358998.1 → XP_054214973.1  integrator complex subunit 15 isoform X4

    4. XM_054358997.1 → XP_054214972.1  integrator complex subunit 15 isoform X3

    RNA

    1. XR_008487751.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96N11.1 GenPept UniProtKB/Swiss-Prot:Q96N11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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