RMT2 protein-arginine N5-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RMT2
Official Full Name: protein-arginine N5-methyltransferase
Primary source: SGD:S000002873
Locus tag: YDR465C
See related: AllianceGenome:SGD:S000002873; FungiDB:YDR465C; VEuPathDB:YDR465C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein arginine N5-methyltransferase activity. Involved in peptidyl-arginine methylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Orthologous to human GAMT (guanidinoacetate N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RMT2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1393336..1394574, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rmt2 has nuclear and cytoplasmic localizations and influences the transcription of MYO1, required for cytokinesis.
Title: The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49, Nup57 and Nup100.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein arginine N5-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein arginine N5-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein arginine N5-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-arginine methylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein-arginine N5-methyltransferase

NP_010753.1

Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1393336..1394574 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180773.1 → NP_010753.1 TPA: protein-arginine N5-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT90, Q03305

UniProtKB/TrEMBL

A6ZZ56, B3LFJ9, C7GKQ7, C8Z624, N1P5P8

Conserved Domains (1) summary

cd02440
Location:244 → 345

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...