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    Ap1m1 adaptor related protein complex 1 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap1m1provided by RGD
    Official Full Name
    adaptor related protein complex 1 subunit mu 1provided by RGD
    Primary source
    RGD:1307653
    See related
    EnsemblRapid:ENSRNOG00000014454 AllianceGenome:RGD:1307653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in endosome to melanosome transport; melanosome organization; and vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle and synapse. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 151.0), Thymus (RPKM 143.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap1m1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17620910..17636431, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17586886..17602410, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19288354..19303818, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2 Neighboring gene family with sequence similarity 32, member A Neighboring gene calcium and integrin binding family member 3 Neighboring gene hematopoietic SH2 domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons. Farías GG, et al. Neuron, 2012 Sep 6. PMID 22958822, Free PMC Article
    2. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. Meyer C, et al. EMBO J, 2000 May 15. PMID 10811610, Free PMC Article
    3. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
    4. AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. Delevoye C, et al. J Cell Biol, 2009 Oct 19. PMID 19841138, Free PMC Article
    5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The primary recognition event that underlies somatodendritic sorting contributes to the evolving view of AP-1 as a global regulator of cell polarity.
      Title: Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125095

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to melanosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome to melanosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in melanosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex subunit mu-1
    Names
    AP-mu chain family member mu1A
    adapter-related protein complex 1 subunit mu-1
    adaptor protein complex AP-1 mu-1 subunit
    adaptor protein complex AP-1 subunit mu-1
    adaptor-related protein complex 1, mu 1 subunit
    adaptor-related protein complex AP-1, mu subunit 1
    clathrin assembly protein complex 1 medium chain 1
    clathrin assembly protein complex 1 mu-1 medium chain 1
    golgi adaptor HA1/AP1 adaptin mu-1 subunit
    mu-adaptin 1
    mu1A-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044239.2 → NP_001037704.1  AP-1 complex subunit mu-1

      See identical proteins and their annotated locations for NP_001037704.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q32Q06
      UniProtKB/TrEMBL
      A0A8I6A2R3, A6K9P8
      Related
      ENSRNOP00000086711.2, ENSRNOT00000115580.2
      Conserved Domains (2) summary
      cd09258
      Location:153 → 422
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:4 → 142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17620910..17636431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094482.2 → XP_038950410.1  AP-1 complex subunit mu-1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q9M5
      Related
      ENSRNOP00000019350.5, ENSRNOT00000019350.6
      Conserved Domains (2) summary
      cd09258
      Location:78 → 347
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cl38905
      Location:14 → 67
      longin-like; Longin-like domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32Q06.3 GenPept UniProtKB/Swiss-Prot:Q32Q06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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