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    Gsta6 glutathione S-transferase alpha 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsta6provided by RGD
    Official Full Name
    glutathione S-transferase alpha 6provided by RGD
    Primary source
    RGD:1565402
    See related
    EnsemblRapid:ENSRNOG00000033402 AllianceGenome:RGD:1565402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 137.9), Testes (RPKM 74.4) and 9 other tissues See more
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    Genomic context

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    See Gsta6 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (31239670..31297809, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (23743262..23806260, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (27475273..27533939, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 1 Neighboring gene ribosomal protein L10A, pseudogene 1 Neighboring gene ERH, mRNA splicing and mitosis factor, pseudogene 1 Neighboring gene Wistar clone pR53P1 p53 pseudogene Neighboring gene KH domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Resveratrol improves health and survival of mice on a high-calorie diet. Baur JA, et al. Nature, 2006 Nov 16. PMID 17086191, Free PMC Article
    2. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
    3. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase A6
    Names
    GST class-alpha member 6
    NP_001019532.1
    XP_006244718.1
    XP_006244719.1
    XP_038939993.1
    XP_038939994.1
    XP_063123651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024361.1 → NP_001019532.1  glutathione S-transferase A6

      See identical proteins and their annotated locations for NP_001019532.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079271
      UniProtKB/Swiss-Prot
      Q6AXY0
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      31239670..31297809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244656.5 → XP_006244718.1  glutathione S-transferase A6 isoform X1

      See identical proteins and their annotated locations for XP_006244718.1

      UniProtKB/Swiss-Prot
      Q6AXY0
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. XM_039084065.2 → XP_038939993.1  glutathione S-transferase A6 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXY0
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. XM_006244657.5 → XP_006244719.1  glutathione S-transferase A6 isoform X1

      See identical proteins and their annotated locations for XP_006244719.1

      UniProtKB/Swiss-Prot
      Q6AXY0
      Related
      ENSRNOP00000031201.2, ENSRNOT00000036813.4
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. XM_039084066.2 → XP_038939994.1  glutathione S-transferase A6 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXY0
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    5. XM_063267581.1 → XP_063123651.1  glutathione S-transferase A6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXY0.1 GenPept UniProtKB/Swiss-Prot:Q6AXY0

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