RER2 ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RER2
Official Full Name: ditrans,polycis-polyprenyl diphosphate synthase
Primary source: SGD:S000000206
Locus tag: YBR002C
See related: AllianceGenome:SGD:S000000206; FungiDB:YBR002C; VEuPathDB:YBR002C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dehydrodolichyl diphosphate synthase activity. Involved in dolichol biosynthetic process; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein glycosylation. Located in endoplasmic reticulum and lipid droplet. Part of dehydrodolichyl diphosphate synthase complex. Used to study cancer. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RER2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (241708..242568, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of Nus1, the non-catalytic subunit of cis-PT from Saccharomyces cerevisiae in complex with Rer2
Title: Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.
the activities of two yeast cis prenyltransferases Rer2p and Srt1p and polyprenol reductase are not co-regulated and reductase may be the rate-limiting enzyme in dolichol synthesis if the amount of polyisoprenoids synthesized exceeds a certain level.
Title: Interplay between the cis-prenyltransferases and polyprenol reductase in the yeast Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to dehydrodolichyl diphosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydrodolichyl diphosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydrodolichyl diphosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dolichol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dehydrodolichyl diphosphate synthase complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ditrans,polycis-polyprenyl diphosphate synthase

NP_009556.1

EC 2.5.1.87

Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

241708..242568 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178350.1 → NP_009556.1 TPA: ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009556.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ03, P35196

UniProtKB/TrEMBL

B3LND8, C7GM47, C8Z3Z8, N1P7X4

Conserved Domains (1) summary

TIGR00055
Location:33 → 258

uppS; undecaprenyl diphosphate synthase