Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Suclg1provided by MGI
Official Full Name: succinate-CoA ligase, GDP-forming, alpha subunitprovided by MGI
Primary source: MGI:MGI:1927234
See related: Ensembl:ENSMUSG00000052738 AllianceGenome:MGI:1927234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sucla1; 1500000I01Rik
Summary: Predicted to enable GDP binding activity; succinate-CoA ligase (ADP-forming) activity; and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 105.3), heart adult (RPKM 103.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.4 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (73225488..73253890)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (73248505..73276907)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
Title: SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity
Title: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Suclg1 (e-PCR), detects polymorphism
- UniSTS:507252

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (ADP-forming) activity	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (ADP-forming) activity	ISO Inferred from Sequence Orthology more info
enables succinate-CoA ligase (GDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (GDP-forming) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in succinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in succinyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of succinate-CoA ligase complex (ADP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (ADP-forming)	ISO Inferred from Sequence Orthology more info	PubMed
part_of succinate-CoA ligase complex (GDP-forming)	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Names: SCS-alpha; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; succinyl-CoA synthetase subunit alpha

NP_063932.2

EC 6.2.1.4

EC 6.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.