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    GCV3 glycine decarboxylase subunit H [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCV3
    Official Full Name
    glycine decarboxylase subunit H
    Primary source
    SGD:S000000042
    Locus tag
    YAL044C
    See related
    AllianceGenome:SGD:S000000042; FungiDB:YAL044C; VEuPathDB:YAL044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lipoic acid binding activity. Involved in glycine catabolic process; one-carbon metabolic process; and protein lipoylation. Located in mitochondrion. Part of glycine cleavage complex. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GCV3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (57950..58462, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Bol3p Neighboring gene Bol1p Neighboring gene RNA-processing protein PTA1 Neighboring gene Erv46p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria. Chen B, et al. Front Bioeng Biotechnol, 2020. PMID 32974306, Free PMC Article
    2. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong SP, et al. J Biol Chem, 1999 Apr 9. PMID 10187845
    3. Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. Piper MD, et al. FEMS Yeast Res, 2002 Mar. PMID 12702322
    4. The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Hermes FA, et al. Yeast, 2013 Oct. PMID 23960015, Free PMC Article
    5. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. Piper MD, et al. J Biol Chem, 2000 Oct 6. PMID 10871621

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycine decarboxylation via glycine cleavage system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein lipoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glycine cleavage complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycine cleavage complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycine cleavage complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine decarboxylase subunit H
    NP_009355.3
    • H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      57950..58462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178189.1 → NP_009355.3  TPA: glycine decarboxylase subunit H [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009355.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH2, P39726
      UniProtKB/TrEMBL
      A7A0C2, B3LUY0, C7GPJ3, C8Z3E4, G2W8I6, N1P917
      Conserved Domains (1) summary
      TIGR00527
      Location:40 → 169
      gcvH; glycine cleavage system H protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39726.3

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