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    TRM112 RNA methylation protein TRM112 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRM112
    Official Full Name
    RNA methylation protein TRM112
    Primary source
    SGD:S000005329
    Locus tag
    YNR046W
    See related
    AllianceGenome:SGD:S000005329; FungiDB:YNR046W; VEuPathDB:YNR046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to protein methyltransferase activity; rRNA (guanine) methyltransferase activity; and tRNA (guanine(10)-N2)-methyltransferase activity. Involved in RNA processing and peptidyl-glutamine methylation. Located in cytoplasm and nucleolus. Part of eRF1 methyltransferase complex and tRNA (m2G10) methyltransferase complex. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRM112 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (707788..708195)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Aga1p Neighboring gene Pet494p Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene putative aminophospholipid translocase regulatory protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of yeast (m2G10) methyltransferase (Trm11 and Trm112 complex) in a wheat germ cell-free translation system. Okada K, et al. Nucleic Acids Symp Ser (Oxf), 2009. PMID 19749381
    2. Trmt112 gene expression in mouse embryonic development. Gu T, et al. Acta Histochem Cytochem, 2012 Apr 26. PMID 22685353, Free PMC Article
    3. Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. Chen C, et al. PLoS One, 2011. PMID 21687733, Free PMC Article
    4. Mechanism of activation of methyltransferases involved in translation by the Trm112 'hub' protein. Liger D, et al. Nucleic Acids Res, 2011 Aug. PMID 21478168, Free PMC Article
    5. Physical and functional interaction between the methyltransferase Bud23 and the essential DEAH-box RNA helicase Ecm16. Sardana R, et al. Mol Cell Biol, 2014 Jun. PMID 24710271, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
      Title: The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
    2. Trm112 is required for efficient ribosome synthesis and progression through mitosis
      Title: Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.
    3. Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast
      Title: Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast.
    4. The Ynr046w eRF1 methyltransferase subunit is shared by the tRNA methyltransferase Trm11p and probably by two other enzymes containing a Rossman fold
      Title: The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to rRNA (guanine) methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to tRNA (guanine(10)-N2)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to tRNA (guanine(10)-N2)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA methyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-glutamine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eRF1 methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA (m2G10) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m2G10) methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA methylation protein TRM112
    NP_014444.1
    • Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      707788..708195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183223.1 → NP_014444.1  TPA: RNA methylation protein TRM112 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M1, P53738
      UniProtKB/TrEMBL
      A6ZSC0, B3LPJ7, C7GLL1, C8ZFS5, G2WLA3, N1NZS7
      Conserved Domains (1) summary
      cd21089
      Location:2 → 130
      Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53738.1

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