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    PCL7 Pcl7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PCL7
    Official Full Name
    Pcl7p
    Primary source
    SGD:S000001312
    Locus tag
    YIL050W
    See related
    AllianceGenome:SGD:S000001312; FungiDB:YIL050W; VEuPathDB:YIL050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; and regulation of protein stability. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PCL7 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (258913..259770)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L34B Neighboring gene isoleucine biosynthesis protein MMF1 Neighboring gene putative polyprenol reductase Neighboring gene putative aminophospholipid-translocating P4-type ATPase NEO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Phosphorylation of YLR190w by PAP1 PHO85 kinase complex]. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Mar. PMID 12006994
    2. Cloning and Expression of a Novel PHO85 Associated Protein PAP1 Gene of Saccharomyces cerevisiae. Wu JS, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1998. PMID 12174291
    3. Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81. Lee M, et al. Mol Microbiol, 2000 Oct. PMID 11069666
    4. Analysis of phosphorylation of YJL084c, a yeast protein. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Jul. PMID 12098764
    5. Yeast Gcn4p stabilization is initiated by the dissociation of the nuclear Pho85p/Pcl5p complex. Bömeke K, et al. Mol Biol Cell, 2006 Jul. PMID 16611745, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of glycogen catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pcl7p
    NP_012214.3
    • Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      258913..259770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179400.3 → NP_012214.3  TPA: Pcl7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012214.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN1, P40186
      UniProtKB/TrEMBL
      A6ZVL9, B3LTQ6, C8ZAJ6, G2WG95, N1P0L4
      Conserved Domains (1) summary
      pfam08613
      Location:108 → 264
      Cyclin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40186.3

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