Cd69 Cd69 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd69provided by RGD
Official Full Name: Cd69 moleculeprovided by RGD
Primary source: RGD:61318
See related: EnsemblRapid:ENSRNOG00000056783 AllianceGenome:RGD:61318
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium ion binding activity. Predicted to be involved in cellular response to xenobiotic stimulus; negative regulation of T cell migration; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in external side of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human CD69 (CD69 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 246.4), Spleen (RPKM 80.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164411485..164419403, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (162725446..162733364, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163041147..163049065, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in complement activation, lectin pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 2 member A

Names: CD69 antigen; early activation antigen CD69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134327.2 → NP_599154.1 C-type lectin domain family 2 member A

See identical proteins and their annotated locations for NP_599154.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6G1Q9, D9Z4I9, Q5M851

Related

ENSRNOP00000105129.1, ENSRNOT00000153540.1

Conserved Domains (1) summary

cd03593
Location:85 → 196

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)