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    Cops2 COP9 signalosome subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 261736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cops2provided by RGD
    Official Full Name
    COP9 signalosome subunit 2provided by RGD
    Primary source
    RGD:628791
    See related
    EnsemblRapid:ENSRNOG00000008744 AllianceGenome:RGD:628791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CSN2; Trip15
    Summary
    Predicted to enable transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and neuron differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 355.9), Heart (RPKM 306.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cops2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133537729..133563493, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113084174..113110090, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118109394..118137125, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 4 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Alves CRR, et al. Mol Metab, 2020 Sep. PMID 32408015, Free PMC Article
    2. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Akiyama H, et al. Brain Res Dev Brain Res, 2003 Jan 10. PMID 12524175
    3. Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Tenbaum SP, et al. Dev Biol, 2003 Feb 1. PMID 12606288
    4. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. Akiyama H, et al. J Biol Chem, 2003 Mar 21. PMID 12522100
    5. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Lykke-Andersen K, et al. Mol Cell Biol, 2003 Oct. PMID 12972599, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
      Title: Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
    2. Expressed at an early stage of neuronal differentiaation.
      Title: Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trophectodermal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 2
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 2
    JAB1-containing signalosome subunit 2
    SGN2
    TR-interacting protein 15
    TRIP-15
    alien homolog
    signalosome subunit 2
    thyroid receptor-interacting protein 15
    tyroid receptor interacting protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429755.1 → NP_001416684.1  COP9 signalosome complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_153297.2 → NP_695209.1  COP9 signalosome complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_695209.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P61203, Q6P731
      UniProtKB/TrEMBL
      A6HPX8
      Conserved Domains (2) summary
      COG5159
      Location:40 → 434
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:309 → 413
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      133537729..133563493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234901.5 → XP_006234963.1  COP9 signalosome complex subunit 2 isoform X1

      Related
      ENSRNOP00000075473.2, ENSRNOT00000084154.3
      Conserved Domains (2) summary
      COG5159
      Location:40 → 441
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:316 → 420
      PCI; PCI domain

    2. XM_039104395.2 → XP_038960323.1  COP9 signalosome complex subunit 2 isoform X2

      Conserved Domains (1) summary
      COG5159
      Location:40 → 403
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

    3. XM_063283173.1 → XP_063139243.1  COP9 signalosome complex subunit 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61203.1 GenPept UniProtKB/Swiss-Prot:P61203

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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