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    Odad4 outer dynein arm docking complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odad4provided by RGD
    Official Full Name
    outer dynein arm docking complex subunit 4provided by RGD
    Primary source
    RGD:1311859
    See related
    EnsemblRapid:ENSRNOG00000017473 AllianceGenome:RGD:1311859
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ttc25; RGD1311859
    Summary
    Predicted to be involved in mucociliary clearance and protein localization to motile cilium. Predicted to act upstream of or within cerebrospinal fluid circulation; epithelial cilium movement involved in determination of left/right asymmetry; and outer dynein arm assembly. Predicted to be located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Predicted to be part of outer dynein arm docking complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 76.0), Adrenal (RPKM 27.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Odad4 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85980440..86008943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85480089..85508603)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88459490..88488237)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene transfer RNA serine (anticodon AGA) 28 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene NFKB inhibitor interacting Ras-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm docking complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 4
    Names
    tetratricopeptide repeat domain 25
    tetratricopeptide repeat protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107049.1 → NP_001100519.1  outer dynein arm-docking complex subunit 4

      See identical proteins and their annotated locations for NP_001100519.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A0G2KAE9, A6HJ41, B1WCA2
      Related
      ENSRNOP00000075373.1, ENSRNOT00000080231.3
      Conserved Domains (3) summary
      sd00006
      Location:18 → 43
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:18 → 80
      TPR_11; TPR repeat
      pfam13424
      Location:400 → 470
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      85980440..86008943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086089.2 → XP_038942017.1  outer dynein arm-docking complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      G3V9Y3
      Related
      ENSRNOP00000063052.2, ENSRNOT00000067559.4
      Conserved Domains (3) summary
      TIGR00990
      Location:22 → 103
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:18 → 43
      TPR; TPR repeat [structural motif]
      pfam17874
      Location:325 → 472
      TPR_MalT; MalT-like TPR region

    2. XM_039086088.2 → XP_038942016.1  outer dynein arm-docking complex subunit 4 isoform X1

      Conserved Domains (3) summary
      sd00006
      Location:86 → 124
      TPR; TPR repeat [structural motif]
      cd06503
      Location:251 → 329
      ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
      pfam17874
      Location:98 → 245
      TPR_MalT; MalT-like TPR region
    Nucleotide Protein Strain
    Heading Accession and Version

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