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    Klhl6 kelch-like family member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl6provided by RGD
    Official Full Name
    kelch-like family member 6provided by RGD
    Primary source
    RGD:1307521
    See related
    EnsemblRapid:ENSRNOG00000001908 AllianceGenome:RGD:1307521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in B cell receptor signaling pathway; germinal center formation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 206.0), Spleen (RPKM 153.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl6 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94475262..94514653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80970917..81010593)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84745958..84785315)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 24 Neighboring gene transfer RNA threonine (anticodon AGU) 24 Neighboring gene EWS RNA-binding protein 5 Neighboring gene EWS RNA-binding protein 3 Neighboring gene uncharacterized LOC120095700 Neighboring gene microRNA 6323 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Kroll J, et al. Mol Cell Biol, 2005 Oct. PMID 16166635, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in germinal center formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 6
    Names
    kelch-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105867.1 → NP_001099337.1  kelch-like protein 6

      See identical proteins and their annotated locations for NP_001099337.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A6JSC3, D4A1Z1
      Related
      ENSRNOP00000002617.6, ENSRNOT00000002617.8
      Conserved Domains (6) summary
      smart00612
      Location:420 → 466
      Kelch; Kelch domain
      smart00225
      Location:71 → 163
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:60 → 163
      BTB; BTB/POZ domain
      pfam01344
      Location:457 → 501
      Kelch_1; Kelch motif
      pfam07707
      Location:172 → 274
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      94475262..94514653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270327.1 → XP_063126397.1  kelch-like protein 6 isoform X2

    2. XM_006248594.3 → XP_006248656.1  kelch-like protein 6 isoform X1

      Conserved Domains (5) summary
      smart00612
      Location:323 → 369
      Kelch; Kelch domain
      sd00038
      Location:271 → 308
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:1 → 66
      BTB; BTB/POZ domain
      pfam01344
      Location:360 → 404
      Kelch_1; Kelch motif
      pfam07707
      Location:75 → 177
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein Strain
    Heading Accession and Version

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