Atpsckmt ATP synthase c subunit lysine N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atpsckmtprovided by RGD
Official Full Name: ATP synthase c subunit lysine N-methyltransferaseprovided by RGD
Primary source: RGD:1560629
See related: EnsemblRapid:ENSRNOG00000022347 AllianceGenome:RGD:1560629
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam173b; RGD1560629
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in several processes, including peptidyl-lysine trimethylation; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; and positive regulation of sensory perception of pain. Predicted to be located in mitochondrial crista. Predicted to be active in mitochondrion. Orthologous to human ATPSCKMT (ATP synthase c subunit lysine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 118.2), Muscle (RPKM 109.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (84313991..84329195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (82603086..82618325)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (84678892..84694152)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133157 (e-PCR)
- UniSTS:216440

AI104594 (e-PCR)
- UniSTS:261570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine trimethylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine trimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial ATP synthesis coupled proton transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP synthase subunit C lysine N-methyltransferase

Names: family with sequence similarity 173, member B; protein FAM173B; protein N-lysine methyltransferase FAM173B

NP_001102648.1

EC 2.1.1.-

XP_038958769.1

EC 2.1.1.-

XP_038958771.1

EC 2.1.1.-

XP_038958772.1

EC 2.1.1.-

XP_038958773.1

EC 2.1.1.-

XP_038958774.1

EC 2.1.1.-

XP_038958776.1

EC 2.1.1.-

XP_038958777.1

EC 2.1.1.-

XP_063138422.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109178.1 → NP_001102648.1 ATP synthase subunit C lysine N-methyltransferase

See identical proteins and their annotated locations for NP_001102648.1

Status: PROVISIONAL

Source sequence(s)

CH473992

UniProtKB/Swiss-Prot

D3ZLY0

UniProtKB/TrEMBL

A6JN03

Related

ENSRNOP00000041476.3, ENSRNOT00000046325.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

84313991..84329195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102841.2 → XP_038958769.1 ATP synthase subunit C lysine N-methyltransferase isoform X1

Conserved Domains (1) summary

cl17173
Location:83 → 118

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039102844.1 → XP_038958772.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039102846.1 → XP_038958774.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039102848.1 → XP_038958776.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063282352.1 → XP_063138422.1 ATP synthase subunit C lysine N-methyltransferase isoform X2
XM_039102849.2 → XP_038958777.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039102843.2 → XP_038958771.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039102845.2 → XP_038958773.1 ATP synthase subunit C lysine N-methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:9 → 105

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...