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    Acsm1 acyl-CoA synthetase medium-chain family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsm1provided by RGD
    Official Full Name
    acyl-CoA synthetase medium-chain family member 1provided by RGD
    Primary source
    RGD:1306813
    See related
    EnsemblRapid:ENSRNOG00000042084 AllianceGenome:RGD:1306813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bucs1
    Summary
    Predicted to enable benzoate-CoA ligase activity; decanoate-CoA ligase activity; and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in mitochondrial matrix. Orthologous to human ACSM1 (acyl-CoA synthetase medium chain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 743.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsm1 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183417052..183451897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173985715..174020565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189359374..189395277)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene RGD1559600 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene uncharacterized LOC134483776 Neighboring gene THUMP domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner. Oka Y, et al. Eur J Biochem, 2003 May. PMID 12709059
    2. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. Vessey DA, et al. Biochim Biophys Acta, 1999 Aug 5. PMID 10434065
    3. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, et al. J Biol Chem, 2001 Sep 21. PMID 11470804
    4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables benzoate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables decanoate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM1, mitochondrial
    Names
    butyryl Coenzyme A synthetase 1
    NP_001101972.2
    XP_063123671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108502.2 → NP_001101972.2  acyl-coenzyme A synthetase ACSM1, mitochondrial

      See identical proteins and their annotated locations for NP_001101972.2

      Status: PROVISIONAL

      Source sequence(s)
      BC168985
      UniProtKB/TrEMBL
      A0A0G2K8G2, B5DFA3
      Related
      ENSRNOP00000099262.1, ENSRNOT00000129689.1
      Conserved Domains (2) summary
      COG0365
      Location:46 → 570
      Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
      cl17068
      Location:46 → 573
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183417052..183451897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267601.1 → XP_063123671.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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