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    Dapl1 death associated protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362136, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dapl1provided by RGD
    Official Full Name
    death associated protein-like 1provided by RGD
    Primary source
    RGD:1309610
    See related
    EnsemblRapid:ENSRNOG00000005743 AllianceGenome:RGD:1309610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309610
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of CD8-positive, alpha-beta T cell activation; and ribosome hibernation. Orthologous to human DAPL1 (death associated protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 36.2), Thymus (RPKM 30.0) and 1 other tissue See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Dapl1 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64369734..64389677)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (43960993..43980940)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45538408..45559281)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486285 Neighboring gene uncharacterized LOC134486364 Neighboring gene U6 spliceosomal RNA Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene uncharacterized LOC134486097

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosome hibernation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    death-associated protein-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108582.1NP_001102052.1  death-associated protein-like 1

      See identical proteins and their annotated locations for NP_001102052.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      B5DEQ2, F7FMI3
      Related
      ENSRNOP00000007632.4, ENSRNOT00000007632.7
      Conserved Domains (1) summary
      pfam15228
      Location:13106
      DAP; Death-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64369734..64389677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)