Myh6 myosin heavy chain 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh6provided by RGD
Official Full Name: myosin heavy chain 6provided by RGD
Primary source: RGD:62029
See related: EnsemblRapid:ENSRNOG00000025757 AllianceGenome:RGD:62029
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myh7; Myhca; Myosin-7; MyHC-beta; MyHC-slow
Summary: Enables several functions, including ATP binding activity; calcium-dependent ATPase activity; and identical protein binding activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine and muscle contraction. Located in myofibril. Part of muscle myosin complex. Biomarker of congestive heart failure; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 38771.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32388102..32413663, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28418120..28442316, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33605653..33629730, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
Title: T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
data provide an insight into mechanisms of involvement of myosin VI in nuclear processes via interaction with nuclear proteins and support a notion for important role(s) for myosin VI in gene expression
Title: Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.
Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
Title: Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
L-arginine protection of contractile performance might be related to increased capacity for nitric oxide production and the up-regulation of MYH7 which may compensate for the marked down-regulation of the major MYH6 isoform.
Title: l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
TnT mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 and hypertrophic cardiomyopathy in the presence of MYH7.
Title: Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms.
Myosin VI was recruited to secretory granules in a Ca(2+)-dependent manner.
Title: Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin.
Provide evidence that specific epigenetic phenomena modulate myosin heavy chain gene expression in altered thyroid states.
Title: Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.
There is a close positive relationship between T3 and beta-MHC AS RNA in both the atria and ventricles, while demonstrating for the first time that alpha- and beta-MHC expression is not coupled in the atria.
Title: Differential regulation of the myosin heavy chain genes alpha and beta in rat atria and ventricles: role of antisense RNA.
Suggest the involvement of epigenetic processes in the developmental regulation of cardiac myosin heavy chain gene locus.
Title: Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes.
A repressive role of AP-1 in alpha-MHC expression and its possible involvement in the transition from compensatory hypertrophy to heart failure in chronic volume overload.
Title: Overt expression of AP-1 reduces alpha myosin heavy chain expression and contributes to heart failure from chronic volume overload.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE101980 (e-PCR)
- UniSTS:243788

Myhca (e-PCR), detects polymorphism
- UniSTS:143961

BI283646 (e-PCR)
- UniSTS:243582

RH138715 (e-PCR)
- UniSTS:220802

MYH6 (e-PCR)
- UniSTS:511900

Myh7 (e-PCR), detects polymorphism
- UniSTS:530876

BE107704 (e-PCR)
- UniSTS:247017

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent ATPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
involved_in adult heart development	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrial cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 3,3',5-triiodo-L-thyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle filament sliding	IEA Inferred from Electronic Annotation more info
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myofibril assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in visceral muscle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visceral muscle development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle myosin complex	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IEA Inferred from Electronic Annotation more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-6

Names: Myosin heavy chain 7; myHC-alpha; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin, heavy chain 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017239.2 → NP_058935.2 myosin-6

See identical proteins and their annotated locations for NP_058935.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P02563, Q63351

UniProtKB/TrEMBL

A6KGY0

Related

ENSRNOP00000023301.3, ENSRNOT00000023302.4

Conserved Domains (3) summary

cd01377
Location:99 → 768

MYSc_class_II; class II myosins, motor domain

pfam01576
Location:848 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 72

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32388102..32413663 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274186.1 → XP_063130256.1 myosin-6 isoform X2

UniProtKB/TrEMBL

A0A8I6A2T6, G3V885
XM_017599641.3 → XP_017455130.1 myosin-6 isoform X2

UniProtKB/TrEMBL

A0A8I6A2T6, G3V885
XM_039093219.2 → XP_038949147.1 myosin-6 isoform X1

UniProtKB/Swiss-Prot

P02563, Q63351

UniProtKB/TrEMBL

A6KGY0

Conserved Domains (3) summary

cd01377
Location:99 → 768

MYSc_class_II; class II myosins, motor domain

pfam01576
Location:848 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_063274185.1 → XP_063130255.1 myosin-6 isoform X2

UniProtKB/TrEMBL

A0A8I6A2T6, G3V885
XM_063274184.1 → XP_063130254.1 myosin-6 isoform X1

UniProtKB/Swiss-Prot

P02563, Q63351

UniProtKB/TrEMBL

A6KGY0