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    Ndst3 N-deacetylase and N-sulfotransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndst3provided by RGD
    Official Full Name
    N-deacetylase and N-sulfotransferase 3provided by RGD
    Primary source
    RGD:1310960
    See related
    EnsemblRapid:ENSRNOG00000015781 AllianceGenome:RGD:1310960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylglucosamine deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity; and heparan sulfate N-deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 68.8), Spleen (RPKM 7.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndst3 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (214386804..214552739, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (211702728..211868159, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (227736491..227903657, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene serine protease 12 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene ETS variant transcription factor 5, pseudogene 4 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. Aikawa J, et al. J Biol Chem, 1999 Jan 29. PMID 9915799
    2. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. Aikawa J, et al. J Biol Chem, 2001 Feb 23. PMID 11087757
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparan sulfate N-deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
    Names
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
    N-deacetylase/N-sulfotransferase 3
    NP_001178645.1
    XP_006233330.1
    XP_017446275.1
    XP_038958023.1
    XP_038958024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191716.1 → NP_001178645.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

      See identical proteins and their annotated locations for NP_001178645.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HVJ7, D4ABE3
      Related
      ENSRNOP00000021335.1, ENSRNOT00000021335.5
      Conserved Domains (2) summary
      pfam00685
      Location:595 → 846
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 506
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      214386804..214552739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590786.3 → XP_017446275.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

      UniProtKB/TrEMBL
      A6HVJ7, D4ABE3
      Conserved Domains (2) summary
      pfam00685
      Location:595 → 846
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 506
      HSNSD; heparan sulfate-N-deacetylase

    2. XM_006233268.4 → XP_006233330.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006233330.1

      UniProtKB/TrEMBL
      A6HVJ7, D4ABE3
      Conserved Domains (2) summary
      pfam00685
      Location:595 → 846
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 506
      HSNSD; heparan sulfate-N-deacetylase

    3. XM_039102095.1 → XP_038958023.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam12062
      Location:20 → 506
      HSNSD; heparan sulfate-N-deacetylase

    4. XM_039102096.2 → XP_038958024.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X3

      Conserved Domains (1) summary
      pfam12062
      Location:20 → 506
      HSNSD; heparan sulfate-N-deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version

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