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    Myl7 myosin light chain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myl7provided by RGD
    Official Full Name
    myosin light chain 7provided by RGD
    Primary source
    RGD:1308262
    See related
    EnsemblRapid:ENSRNOG00000014409 AllianceGenome:RGD:1308262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to be located in A band and dendritic spine. Predicted to be active in myofibril. Orthologous to human MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 9604.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myl7 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84994644..84997173, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80780684..80783259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86144770..86147075, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 2, accessory subunit Neighboring gene uncharacterized LOC108352788 Neighboring gene glucokinase Neighboring gene uncharacterized LOC120096653 Neighboring gene YKT6 v-SNARE homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity. Richard-Bulteau H, et al. Am J Physiol Cell Physiol, 2008 Feb. PMID 18077604
    2. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Grimm M, et al. Cardiovasc Res, 2005 Jan 1. PMID 15621049
    3. An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Nishigaki R, et al. Biochem Biophys Res Commun, 2002 Jul 5. PMID 12083776
    4. Direct interaction of myosin regulatory light chain with the NMDA receptor. Amparan D, et al. J Neurochem, 2005 Jan. PMID 15663482
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin regulatory light chain 2, atrial isoform
    Names
    myosin, light chain 7, regulatory
    myosin, light polypeptide 7, regulatory

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106017.1 → NP_001099487.1  myosin regulatory light chain 2, atrial isoform

      See identical proteins and their annotated locations for NP_001099487.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A6IKQ8, B1WC41
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 141
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84994644..84997173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251216.4 → XP_006251278.1  myosin regulatory light chain 2, atrial isoform isoform X1

      UniProtKB/TrEMBL
      B1WC41, F1M7K3
      Related
      ENSRNOP00000019335.6, ENSRNOT00000019335.8
      Conserved Domains (2) summary
      COG5126
      Location:22 → 169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:36 → 132
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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